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|抗原||Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This Caspase 8 antibody is un-conjugated 其他选择|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|Supplier||Log in to see|
Caspase 8抗体详情Caspase 8目标详情 使用细节 贮存及处理 图像
|特异性||Caspase-8 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-8 isoform A.|
|纯化方法||Affinity chromatography purified via peptide column|
|免疫原||Virus Casp-8 / FLICE / MACH / Mch5 (C-Terminus) Peptide|
Caspase 8目标详情Caspase 8抗体详情 使用细节 贮存及处理 图像 回页首
|别名||Caspase-8 (CASP8 Antibody 摘要)|
|背景||Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex (4). The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain, subsequent oligomerization promotes procaspase-8 autoactivation (reviewed in 5). FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis (6).Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP-8, CASP8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MCH5, MORT1-associated CED-3 homolog|
|途径||Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades|
使用细节Caspase 8抗体详情 Caspase 8目标详情 贮存及处理 图像 回页首
ELISA. Western Blot: Caspase-8 antibody can be used for the detection of caspase-8 at 0.5 μg/mL. Depending on cell lines or tissues used, either full-length or other cleavage products maybe observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理Caspase 8抗体详情 Caspase 8目标详情 使用细节 图像 回页首
|缓冲液||PBS containing 0.02 % sodium azide.|
|注意事项||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存方法||Store the antibody undiluted at 2-8 °C.|