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TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 33-423)

Details for Product anti-NTRK1 Antibody No. ABIN969444, 供应商: Log in to see
抗原
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Alternatives
anti-人 TRKA 抗体 for Cell Culture
抗原表位
AA 33-423
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适用

415
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2
宿主
小鼠
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4
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克隆类型 (克隆位点)
单克隆 ()
标记
This TRKA antibody is un-conjugated
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应用范围
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
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19
8
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2
1
Supplier
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免疫原 Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
克隆位点 6B2
亚型 IgG1
纯化方法 Ascites
别名 TrkA (NTRK1 Antibody 摘要)
背景 TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
分子量 87.4 kDa
基因ID 4914
HGNC 4914
研究领域 Cancer
途径 RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
应用备注 ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
限制 仅限研究用
状态 Liquid
缓冲液 Ascitic fluid containing 0.03 % sodium azide.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
储存方法 4°C, -20°C for long term storage
厂商提供的图像
Immunocytochemistry (ICC) image for anti-TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 33-423) (ABIN969444) Figure 1: Confocal immunofluorescence analysis of PC-12 cells using TrkA mouse mAb (g...
Western Blotting (WB) image for anti-TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 33-423) (ABIN969444) Figure 2: Western blot analysis using TrkA mouse mAb against extracellular domain of ...
有引用在: Geetha, Wooten: "TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, 2008 (PubMed).

Schulte, Kuhfittig-Kulle, Klein-Hitpass, Schramm, Biard, Pfeiffer, Eggert: "Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells." in: DNA repair, Vol. 7, Issue 10, pp. 1757-64, 2008 (PubMed).