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MLH1 抗体 (AA 381-483)

Name: MLH1 抗体 (AA 381-483)
Brand: antibodies-online
SKU: ABIN969285
Availability: OutOfStock

MLH1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 4C9C7 unconjugated

Western blot analysis using MLH1 mouse mAb against Hela (1), MCF-7 (2) and A549 (3), Jurkat (4), 2R75 (5) and COS (6) cell lysate.

Confocal immunofluorescence analysis of Hela cells using MLH1 mouse mAb (green), showing nuclear localization.

Immunohistochemical analysis of paraffin-embedded human rectum cancer (left) and ovarian cancer (right) tissues, showing nuclear localization with DAB staining using MLH1 mouse mAb.

IHC

3 images

(3 references)

产品编号 ABIN969285

发货至: 中国

Datasheet as PDF

抗原 See all MLH1 抗体

MLH1 (MutL Homolog 1 (MLH1))
抗原表位
15

10

9

8

7

6

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 381-483
适用
83

22

21

3

3

2

2

2

2

2

2

2

2

1

1

1
人, 猴
宿主
69

14
小鼠
Compatible Secondaries
克隆类型
63

20
单克隆
标记
48

5

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1
This MLH1 antibody is un-conjugated
应用范围
48

34

20

13

13

13

10

9

7

5

3

2

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

纯化方法

purified

免疫原

Purified recombinant fragment of MLH1 (aa381-483) expressed in E. coli.

克隆位点

4C9C7

亚型

IgG1

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anti-MutL Homolog 1 (MLH1) (Internal Region) antibody
MLH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 373-735) antibody
MLH1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutL Homolog 1 (MLH1) (AA 452-480) antibody
MLH1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Ascitic fluid containing 0.03 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

4°C, -20°C for long term storage
Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, (2008) (PubMed).

Latta, Mohan, Issekutz: "CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis." in: Immunology, Vol. 121, Issue 4, pp. 555-64, (2007) (PubMed).

Zeng, Kinsella: "A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells." in: Autophagy, Vol. 3, Issue 4, pp. 368-70, (2007) (PubMed).
抗原

MLH1 (MutL Homolog 1 (MLH1))

别名

MLH1 (MLH1 产品)

别名

CG11482 antibody, Dmel\\CG11482 antibody, dmlh-1 antibody, dmlh1 antibody, zgc:66301 antibody, MLH1 antibody, LOC100232198 antibody, 1110035C23Rik antibody, AI317206 antibody, AI325952 antibody, AI561766 antibody, COCA2 antibody, FCC2 antibody, HNPCC antibody, HNPCC2 antibody, hMLH1 antibody, mutL homolog 1 antibody, CG11482 gene product from transcript CG11482-RB antibody, mutL homolog 1 S homeolog antibody, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antibody, DNA mismatch repair protein Mlh1 antibody, MLH1 antibody, Mlh1 antibody, mlh1.S antibody, mlh1 antibody, LOC588545 antibody

背景

Description: DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
Aliases: FCC2, COCA2, HNPCC

分子量

85 kDa

基因ID

4292

HGNC

4292

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response