KSHVORF45 抗体
(3 references)-
- 抗原
- KSHVORF45
- 适用
- Human Herpesvirus 8 (HHV-8)
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
- 应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of KSHV ORF45 expressed in E. coli.
- 克隆位点
- 2D4A5
- 亚型
- IgG1
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-
- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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-
: "Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury." in: Anesthesiology, Vol. 99, Issue 5, pp. 1175-9, (2003) (PubMed).
: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).
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: "Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury." in: Anesthesiology, Vol. 99, Issue 5, pp. 1175-9, (2003) (PubMed).
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- 抗原
- KSHVORF45
- 物质类
- Viral Protein
- 背景
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Description: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Aliases: ORF45
- 基因ID
- 4961474
- HGNC
- 4961474
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