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Hexokinase 2 抗体

HK2 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3D3 unconjugated
产品编号 ABIN969196
发货至: 中国
  • 抗原 See all Hexokinase 2 (HK2) 抗体
    Hexokinase 2 (HK2)
    适用
    • 79
    • 30
    • 24
    • 5
    • 5
    • 4
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    • 3
    • 3
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    • 1
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    宿主
    • 69
    • 19
    小鼠
    克隆类型
    • 69
    • 19
    单克隆
    标记
    • 53
    • 8
    • 8
    • 4
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    • 1
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    This Hexokinase 2 antibody is un-conjugated
    应用范围
    • 71
    • 37
    • 36
    • 13
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    • 11
    • 10
    • 5
    • 4
    • 2
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human HK2 expressed in E. coli.
    克隆位点
    3D3
    亚型
    IgG1
    Top Product
    Discover our top product HK2 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • He, Bi, Zheng, Dai, Han, Liang, Ye, Zeng, Zhu, Zhong: "Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 26, Issue 3, pp. 303-8, (2009) (PubMed).

    Paudyal, Oriuchi, Paudyal, Higuchi, Nakajima, Endo: "Expression of glucose transporters and hexokinase II in cholangiocellular carcinoma compared using [18F]-2-fluro-2-deoxy-D-glucose positron emission tomography." in: Cancer science, Vol. 99, Issue 2, pp. 260-6, (2008) (PubMed).

    Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, (2006) (PubMed).

  • 抗原
    Hexokinase 2 (HK2)
    别名
    HK2 (HK2 产品)
    别名
    HKII antibody, HXK2 antibody, AI642394 antibody, hexokinase-2 antibody, fi09d05 antibody, fi17h06 antibody, wu:fi09d05 antibody, wu:fi17h06 antibody, wu:fi31b04 antibody, zgc:55926 antibody, HK2 antibody, ARABIDOPSIS THALIANA HEXOKINASE 2 antibody, ATHXK2 antibody, F6F22.11 antibody, F6F22_11 antibody, HEXOKINASE 2 antibody, hexokinase 2 antibody, StHK2 antibody, hexokinase 2 antibody, hexokinase-2 antibody, hexokinase 2 L homeolog antibody, HK2 antibody, Hk2 antibody, hk2 antibody, HXK2 antibody, LOC100032849 antibody, hk2.L antibody, hxk2 antibody, LOC102577690 antibody
    背景

    Description: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases .Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

    Aliases: HKII, HXK2, DKFZp686M1669, HK2

    分子量
    102 kDa
    基因ID
    3099
    HGNC
    3099
    途径
    PI3K-Akt Signaling, Carbohydrate Homeostasis, Warburg Effect
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