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USP7 抗体

USP7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5F11 unconjugated
产品编号 ABIN969186
发货至: 中国
  • 抗原 See all USP7 抗体
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    适用
    • 94
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    宿主
    • 84
    • 8
    • 2
    小鼠
    克隆类型
    • 74
    • 20
    单克隆
    标记
    • 48
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    This USP7 antibody is un-conjugated
    应用范围
    • 73
    • 32
    • 25
    • 14
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    • 12
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    • 4
    • 3
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    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human HAUSP expressed in E. coli.
    克隆位点
    5F11
    亚型
    IgG1
    Top Product
    Discover our top product USP7 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Becker, Marchenko, Maurice, Moll: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." in: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, (2007) (PubMed).

    Lu, Ma, Nguyen, Jones, Oren, Donehower: "The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop." in: Cancer cell, Vol. 12, Issue 4, pp. 342-54, (2007) (PubMed).

  • 抗原
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    别名
    HAUSP (USP7 产品)
    别名
    CG1490 antibody, Dmel\\CG1490 antibody, USP7 antibody, 2210010O09Rik antibody, AA409944 antibody, AA617399 antibody, AU019296 antibody, AW548146 antibody, C80752 antibody, Hausp antibody, HAUSP antibody, TEF1 antibody, UBP antibody, Ubiquitin-specific protease 7 antibody, ubiquitin carboxyl-terminal hydrolase 7 antibody, ubiquitin specific peptidase 7 antibody, Usp7 antibody, LOC100201254 antibody, USP7 antibody
    背景

    Description: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.

    Aliases: TEF1, HAUSP, USP7

    分子量
    128 kDa
    基因ID
    7874
    HGNC
    7874
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