E-cadherin 抗体
(3 references)-
- 抗原 See all E-cadherin (CDH1) 抗体
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
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适用
- 人, 小鼠, 猴
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This E-cadherin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human CDH1 expressed in E. coli.
- 克隆位点
- 7H12
- 亚型
- IgG1
- Top Product
- Discover our top product CDH1 Primary Antibody
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anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 401-500) antibody
CDH1 适用: 人, 小鼠, 大鼠 WB, FACS, ELISA, IHC (p), ICC, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibodyKO Validated CDH1 适用: 人 WB, IF, IP, IHC (p), ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 381-480) antibodyCDH1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (C-Term) antibodyCDH1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 810-890) antibodyCDH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibodyCDH1 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibodyCDH1 适用: 人, 小鼠, 大鼠, Pig, 猴, 犬, 小鸡, 兔, Cow, 马, 豚鼠, Avian, Cat, 驴, 山羊, Hamster, 绵羊 WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibodyCDH1 适用: 人 WB, IHC, IF, StM, ISt 宿主: 小鼠 Monoclonal CDH1-1525 unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 375-631) antibodyCDH1 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 155-707) antibodyCDH1 适用: 人 WB, FACS, ELISA, IF 宿主: 小鼠 Monoclonal 9H2D3 unconjugated
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, (2010) (PubMed).
: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, (2009) (PubMed).
: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, (2009) (PubMed).
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: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, (2010) (PubMed).
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- 抗原
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- 别名
- CDH1 (CDH1 产品)
- 别名
- Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, E-cadherin antibody, cdh1 antibody, si:dz180o5.2 antibody, uvo antibody, lcam antibody, E-Cad antibody, XBcad antibody, l-cam antibody, xcdh1 antibody, cdhc-A antibody, xb-cad antibody, XTCAD-1 antibody, c-cadherin antibody, cadherin-1 antibody, uvomorulin antibody, XB-cadherin antibody, arc-1 antibody, cd324 antibody, cdhe antibody, ecad antibody, AA960649 antibody, E-cad antibody, Ecad antibody, L-CAM antibody, Um antibody, cadherin 1 antibody, si:busm1-180o5.2 antibody, cadherin 1, type 1, E-cadherin (epithelial) antibody, cadherin 1, type 1 S homeolog antibody, CDH1 antibody, si:busm1-180o5.2 antibody, cdh1 antibody, Cdh1 antibody, cdh1.S antibody
- 背景
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Description: E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Aliases: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
- 分子量
- 135 kDa
- 基因ID
- 999
- HGNC
- 999
- 途径
- WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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