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GNAQ 抗体 (AA 22-31)

GNAQ 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IF 宿主: 小鼠 Monoclonal 10-GAQ unconjugated
产品编号 ABIN968914
发货至: 中国
  • 抗原 See all GNAQ 抗体
    GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))
    抗原表位
    • 15
    • 11
    • 9
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-31
    适用
    • 53
    • 24
    • 22
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠, 犬, 小鸡
    宿主
    • 45
    • 7
    • 1
    小鼠
    克隆类型
    • 47
    • 6
    单克隆
    标记
    • 25
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GNAQ antibody is un-conjugated
    应用范围
    • 45
    • 25
    • 13
    • 13
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    小鼠, 大鼠, 小鸡, 犬
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Galphaq aa. 22-31
    克隆位点
    10-GAQ
    亚型
    IgG1
    Top Product
    Discover our top product GNAQ Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Dutt, Kjoller, Giel, Hall, Toksoz: "Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly." in: FEBS letters, Vol. 531, Issue 3, pp. 565-9, (2002) (PubMed).

    Li, Iyengar: "Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 13254-9, (2002) (PubMed).

    Strathmann, Simon: "G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 23, pp. 9113-7, (1991) (PubMed).

  • 抗原
    GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))
    别名
    Galpha q (GNAQ 产品)
    别名
    si:ch73-270f14.2 antibody, CMC1 antibody, G-ALPHA-q antibody, GAQ antibody, SWS antibody, Galphaq antibody, Gnaq antibody, g-alpha-q antibody, gaq antibody, gnaqb antibody, 1110005L02Rik antibody, 6230401I02Rik antibody, AA408290 antibody, AW060788 antibody, Dsk1 antibody, Dsk10 antibody, Gq antibody, GqI antibody, guanine nucleotide binding protein (G protein), q polypeptide antibody, G protein subunit alpha q antibody, guanine nucleotide binding protein (G protein), q polypeptide S homeolog antibody, guanine nucleotide binding protein, alpha q polypeptide antibody, gnaq antibody, GNAQ antibody, Gnaq antibody, gnaq.S antibody
    背景
    The GTP binding regulatory proteins (G proteins) consist of three subunits: alpha, beta, and gamma. These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The alpha subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions. The betagamma subunit complex interacts directly with receptors and the alpha subunit. The Galpha family includes four families: the Galphas family including Galphas , Galphao1f, and Galphat, the Galphai family including Galphai, Galphao, and Galphaz, the Galphaq/Galpha11 family and the Galpha12/13 family. The Galphaq protein is 88% homologus with Galpha11 and both are widely expressed. These G proteins activate phospholipase C proteins, which induce calcium signaling events. G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate Galphaq, phospholipase Cbeta, and induce calcium-dependent activation of calpain. These events promote beta-catenin nuclear export and proteolysis. Galphaq has also been implicated in metabotropic glutamate receptor signaling. Thus, Galphaq isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways.
    分子量
    42 kDa
    途径
    JAK/STAT Signaling, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction
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