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SPTBN1 抗体 (AA 2101-2189)

SPTBN1 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 42-B unconjugated
产品编号 ABIN968882
发货至: 中国
  • 抗原 See all SPTBN1 抗体
    SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))
    抗原表位
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2101-2189
    适用
    • 25
    • 10
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 26
    小鼠
    克隆类型
    • 26
    单克隆
    标记
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPTBN1 antibody is un-conjugated
    应用范围
    • 14
    • 8
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human beta-Spectrin II aa. 2101-2189
    克隆位点
    42-B
    亚型
    IgG1
    Top Product
    Discover our top product SPTBN1 Primary Antibody
  • 应用备注
    For western blot analysis use at 1:1000.
    说明

    Related Products: ABIN968537

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Nicolas, Fournier, Galand, Malbert-Colas, Bournier, Kroviarski, Bourgeois, Camonis, Dhermy, Grandchamp, Lecomte: "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3527-36, (2002) (PubMed).

    Hu, Watanabe, Bennett: "Characterization of human brain cDNA encoding the general isoform of beta-spectrin." in: The Journal of biological chemistry, Vol. 267, Issue 26, pp. 18715-22, (1992) (PubMed).

    Moon, McMahon: "Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4427-33, (1990) (PubMed).

  • 抗原
    SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))
    别名
    beta-Spectrin II (SPTBN1 产品)
    别名
    9930031C03Rik antibody, AL033301 antibody, SPTB2 antibody, Spnb-2 antibody, Spnb2 antibody, elf1 antibody, elf3 antibody, mKIAA4049 antibody, ELF antibody, betaSpII antibody, Spnb1 antibody, spectrin beta, non-erythrocytic 1 antibody, spectrin, beta, non-erythrocytic 1 antibody, Sptbn1 antibody, SPTBN1 antibody
    背景
    Spectrins are central components of the cytoskeleton that form a scaffold below the plasma membrane. Spectrins contain two subunits, alpha and ß, which intertwine to form heterodimers that can self associate into elongated tetramers. alpha-spectin I and ß-spectrin I form heterodimers in red blood cells, while nonerythroid mammalian cells contain heterodimers of alpha-spectin I and II with ß-spectrin I to V. The structure of spectrins includes a succession of triple-helical repeats alongwith various domains, such as SH3 domain, EF hands, PH domains, and binding domains for ankyrin, actin, band 4.1, and calmodulin. alpha-spectrin II is a widely expressed non-erythroid alpha-spectrin that contains an SH3 domain, a calmodulin binding site, and two cleavage sites for proteases, such as calpains and caspase-3. ß-spectrin II is a widely expressed non-erythroid ß-spectrin that contains a C-terminal region that interacts with alpha-spectrins and a PH domain. alpha-spectrin II and ß-spectrin II, like many other spectrins, can form heterodimers that can self associate into tetramers, as well as interact with Band 4.1, F-actin, and other proteins near the plasma membrane. This scaffold of cytoskeletal and plasma membrane proteins is critical for the maintenance of cell structure. This antibody is routinely tested by the Western blot analysis.
    分子量
    280 kDa
    途径
    Regulation of Actin Filament Polymerization, Protein targeting to Nucleus
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