SPTAN1 抗体 (AA 252-371)
(3 references)-
- 抗原 See all SPTAN1 抗体
- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
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抗原表位
- AA 252-371
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适用
- 人, 小鼠, 大鼠, 小鸡, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SPTAN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 犬, 小鸡
- 无交叉反应
- 大鼠, 小鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human alpha-Spectrin II aa. 252-371
- 克隆位点
- 35-alpha
- 亚型
- IgG1
- Top Product
- Discover our top product SPTAN1 Primary Antibody
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anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 950-1130) antibody
SPTAN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2071-2269) antibodySPTAN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) antibodySPTAN1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 1573-1742) antibodySPTAN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) antibodySPTAN1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2351-2475) antibodySPTAN1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal SPTAN1-3351 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 289-408) antibodySPTAN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 977-991) antibodySPTAN1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50708 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 2351-2475) antibodySPTAN1 适用: 人 IHC, ELISA, Coat 宿主: 小鼠 Monoclonal SPTAN1-3352 unconjugated
anti-Spectrin alpha Chain, Brain (SPTAN1) (AA 1004-1181) antibodySPTAN1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3527-36, (2002) (PubMed).
: "Characterization of human brain cDNA encoding the general isoform of beta-spectrin." in: The Journal of biological chemistry, Vol. 267, Issue 26, pp. 18715-22, (1992) (PubMed).
: "Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4427-33, (1990) (PubMed).
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: "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3527-36, (2002) (PubMed).
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- 抗原
- SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
- 别名
- alpha-Spectrin II (SPTAN1 产品)
- 别名
- im:7157190 antibody, wu:fa20e05 antibody, wu:fb33g08 antibody, wu:fk32a10 antibody, zgc:112229 antibody, 2610027H02Rik antibody, Spna-2 antibody, Spna2 antibody, EIEE5 antibody, NEAS antibody, SPTA2 antibody, A2a antibody, IPF antibody, SPECA antibody, spectrin alpha, non-erythrocytic 1 antibody, spectrin, alpha, non-erythrocytic 1 antibody, SPTAN1 antibody, sptan1 antibody, Sptan1 antibody
- 背景
- Spectrins are central components of the cytoskeleton that form a scaffold below the plasma membrane. Spectrins contain two subunits, alpha and beta, which intertwine to form heterodimers that can self associate into elongated tetramers. alpha-spectin I and beta-spectrin I form heterodimers in red blood cells, while nonerythroid mammalian cells contain heterodimers of alpha-spectin I and II with beta-spectrin I to V. The structure of spectrins includes a succession of triple-helical repeats along with various domains, such as SH3 domain, EF hands, PH domains, and binding domains for ankyrin, actin, band 4.1, and calmodulin. alpha-spectrin II is a widely expressed non-erythroid alpha-spectrin that contains an SH3 domain, a calmodulin binding site, and two cleavage sites for proteases, such as calpains and caspase-3. beta-spectrin II is a widely expressed non-erythroid beta-spectrin that contains a C-terminal region that interacts with alpha-spectrins and a PH domain. alpha-spectrin II and beta-spectrin II, like many other spectrins, can form heterodimers that can self associate into tetramers, as well as interact with Band 4.1, F-actin, and other proteins near the plasma membrane. This scaffold of cytoskeletal and plasma membrane proteins is critical for the maintenance of cell structure.
- 分子量
- 250 kDa
- 途径
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
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