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TRIP10 抗体 (AA 411-501)

TRIP10 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 21-CIP4 unconjugated
产品编号 ABIN968876
发货至: 中国
  • 抗原 See all TRIP10 抗体
    TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))
    抗原表位
    • 15
    • 9
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 411-501
    适用
    • 46
    • 34
    • 14
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 60
    • 1
    小鼠
    克隆类型
    • 60
    • 1
    单克隆
    标记
    • 27
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRIP10 antibody is un-conjugated
    应用范围
    • 47
    • 23
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human CIP4 aa. 411-501
    克隆位点
    21-CIP4
    亚型
    IgG1
    Top Product
    Discover our top product TRIP10 Primary Antibody
  • 说明

    Related Products: ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Richnau, Aspenström: "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35060-70, (2001) (PubMed).

    Tian, Nelson, Stewart: "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules." in: The Journal of biological chemistry, Vol. 275, Issue 11, pp. 7854-61, (2000) (PubMed).

    Aspenström: "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton." in: Current biology : CB, Vol. 7, Issue 7, pp. 479-87, (1997) (PubMed).

  • 抗原
    TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))
    别名
    Cip4 (TRIP10 产品)
    别名
    CIP4 antibody, HSTP antibody, STOT antibody, STP antibody, AI646975 antibody, Cip4 antibody, trip10 antibody, thyroid hormone receptor interactor 10 antibody, thyroid hormone receptor interactor 10a antibody, TRIP10 antibody, Trip10 antibody, trip10a antibody
    背景
    Rho family members are small GTP binding proteins that serve as molecular switches for a number of biological processes. They cycle between active GTP-bound and inactive GDP-bound states. CDC42 is a Rho family protein that was identified in membranes of human platelets and placenta. It is the homologue of CDC42Sc, which regulates initiation of bud-site assembly in Saccharomyces cerevisiae. Similarly, CDC42 regulates the function of the mammalian actin cytoskeleton, allowing for efficient cytokinesis and cell morphogenesis. CDC42-interacting protein 4 (CIP4) was identified in a yeast-two hybrid screen for proteins that bind CDC42. Another variant of CIP4, CIP4/2, was identified that contains an extra 56 amino acids and has 71% identity with CIP4 (or CIP4/1). CIP4 contains a C-terminal SH3 domain and an N-terminal domain that is homologous to non-catalyitic motifs in the tyrosine kinase Fer. The mRNA expression of CIP4 is highest in skeletal muscle, heart, and placenta. Overexpression of CIP4 in Swiss 3T3 cells reduces the amount of stress fibers and leads to clustering of CIP4 to foci at the dorsal side of the cells. In addition, CIP4 binds the Rho-GTPase activating protein RICH and the cytoskeletal protein WASP. Coexpression of CIP4 and WASP in Cos-7 cells leads to WASP association with microtubules. Thus, CIP4 is involved in various protein-protein interactions associated with cytoskeletal dynamics. This antibody is routinely tested by western blot analysis.
    分子量
    80 kDa
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