JNK 抗体 (Mitogen-Activated Protein Kinase 8) (pThr183)

Details for Product anti-MAPK8 Antibody No. ABIN968867, 供应商: Log in to see
抗原
  • BSK
  • BSK/DJNK
  • Bsk
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • JNK
  • JNK/SAPK
  • Jnk
  • Junk
  • SAPKa
  • c-Jun
  • dJNK
  • jnk
  • JNK-46
  • JNK1
  • JNK1A2
  • JNK21B1/2
  • PRKM8
  • SAPK1
  • SAPK1c
  • AI849689
  • Prkm8
  • jnk1
  • sapk1
  • T10F20.15
  • mapk8
  • zgc:112379
  • basket
  • mitogen-activated protein kinase 8
  • mitogen-activated protein kinase 8b
  • Protein JNK-1
  • bsk
  • MAPK8
  • Mapk8
  • mapk8
  • ATMPK8
  • mapk8b
  • jnk-1
Alternatives
anti-人 JNK 抗体 for Immunofluorescence (fixed cells)
抗原表位
pThr183
98
54
29
17
16
15
15
15
14
12
10
10
10
10
10
9
8
8
6
5
5
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
411
197
167
23
19
13
8
8
6
4
3
3
3
2
2
2
2
1
1
宿主
小鼠
311
115
3
2
克隆类型 (克隆位点)
单克隆 ()
标记
This JNK antibody is un-conjugated
21
19
15
13
11
11
5
4
3
3
3
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Western Blotting (WB)
326
209
98
76
62
59
39
37
30
20
19
8
4
3
3
2
2
2
1
1
1
1
1
1
1
Supplier
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免疫原 Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
克隆位点 41-JNK-SAPK
亚型 IgG1
交叉反应 小鼠, 大鼠
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 JNK (MAPK8 Antibody 摘要)
背景 The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
分子量 43 & 56 kDa
途径 MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
说明

Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074

限制 仅限研究用
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20°C.
厂商提供的图像
Western Blotting (WB) image for anti-JNK 抗体 (Mitogen-Activated Protein Kinase 8) (pThr183) (ABIN968867) Western blot analysis for JNK/SAPK (pT183/pY185). HeLa cells (Human cervical epithelo...
有引用在: Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, 2001 (PubMed).

Kyriakis, Avruch: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." in: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, 2001 (PubMed).

Muyembe, Maes, Makulu, Ghysels, Vandeven, Vandepitte: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, 2001 (PubMed).

Mohit, Martin, Miller: "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system." in: Neuron, Vol. 14, Issue 1, pp. 67-78, 1995 (PubMed).

Hinton, Henderson, Blanks, Rudnicka, Miller: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, 1988 (PubMed).