Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) 抗体

ABIN968863 产品详细信息, 供应商: Log in to see
抗原
  • Cas
  • Crkas
  • P130CAS
  • CTNND1
  • cas
  • p120
  • Xp120
  • ctnnd
  • p120cas
  • p120ctn
  • p120(ctn)
  • Xp120(ctn)
  • p120-catenin
  • CAS
  • CAS1
  • CASS1
  • CRKAS
  • P130Cas
  • AA409437
  • AU019353
  • Catns
  • Ctnnd
  • P120
  • mKIAA0384
  • CTNND
  • P120CAS
  • P120CTN
  • p120(CAS)
  • p120(CTN)
  • C12orf30
  • MDM20
  • NAP1
  • breast cancer anti-estrogen resistance 1
  • catenin (cadherin-associated protein), delta 1
  • catenin (cadherin associated protein), delta 1
  • N(alpha)-acetyltransferase 25, NatB auxiliary subunit
  • Bcar1
  • ctnnd1
  • CTNND1
  • BCAR1
  • Ctnnd1
  • NAA25
Alternatives
anti-大鼠 Catenin (Cadherin-Associated Protein), delta 1 抗体 for Cytometry by Time of Flight
抗原表位
pTyr228
25
19
15
15
15
10
7
6
5
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
230
123
119
17
13
5
5
5
5
4
4
1
宿主
小鼠
156
77
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
10
9
7
7
6
6
5
5
5
5
5
5
5
5
5
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
119
67
53
47
40
35
32
30
25
9
5
3
2
2
2
2
1
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免疫原 Mouse p120 Catenin (pY228)
克隆位点 21a-p120 Catenin
亚型 IgG1
交叉反应 人, 大鼠
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 p120 Catenin (CTNND1 Antibody 摘要)
背景 The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas)was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
分子量 120 kDa
途径 EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
限制 仅限研究用
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20° C.
厂商提供的图像
 image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) 抗体 (ABIN968863) Human Endothelial cells were treated with#1 mM pervanadate for 15 min at 37°C. The to...
Immunofluorescence (IF) image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) 抗体 (ABIN968863) Eahy cells were serum starved and treated with pervanadate (1mM) for 20 min., then fi...
有引用在: Mariner, Anastasiadis, Keilhack, Böhmer, Wang, Reynolds: "Identification of Src phosphorylation sites in the catenin p120ctn." in: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28006-13, 2001 (PubMed).

背景 Reynolds, Daniel, McCrea, Wheelock, Wu, Zhang: "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8333-42, 1994 (PubMed).