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RIPK2 抗体 (AA 333-532)

RIPK2 适用: 人, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 25-RIG unconjugated
产品编号 ABIN968828
发货至: 中国
  • 抗原 See all RIPK2 抗体
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    抗原表位
    • 12
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 333-532
    适用
    • 69
    • 37
    • 19
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    人, 大鼠, 犬
    宿主
    • 64
    • 6
    • 1
    小鼠
    克隆类型
    • 66
    • 5
    单克隆
    标记
    • 41
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RIPK2 antibody is un-conjugated
    应用范围
    • 54
    • 34
    • 25
    • 10
    • 10
    • 7
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    犬, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human RIP2/RICK aa. 333-532
    克隆位点
    25-RIG
    亚型
    IgG1
    Top Product
    Discover our top product RIPK2 Primary Antibody
  • 说明

    Related Products: ABIN968536, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, (2000) (PubMed).

    Navas, Baldwin, Stewart: "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33684-90, (1999) (PubMed).

  • 抗原
    RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
    别名
    RIP2/RICK (RIPK2 产品)
    别名
    RIPK2 antibody, 2210420D18Rik antibody, CARD3 antibody, CARDIAK antibody, CCK antibody, D4Bwg0615e antibody, RICK antibody, RIP2 antibody, GIG30 antibody, receptor interacting serine/threonine kinase 2 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 2 antibody, receptor-interacting serine-threonine kinase 2 antibody, RIPK2 antibody, Ripk2 antibody
    背景
    Members of the TNFR family (TNFRs, DRs, Fas, lymphotoxin-beta-receptor, CD40, CD30, and OX-40) regulate a variety of cellular responses, such as cell activation, proliferation, differentiation, NF-kappaB activation, and apoptosis. Signaling through TNFR family members involves several families of receptor-associated proteins. RIP and RIP2 (RICK/Cardiak) are ser/thr kinase adaptor molecules that associate with TNFR complexes. Both RIPs contain homologous N-teriminal ser/thr kinase domains, but RIP contains a C-terminal death domain, while RIP2 contains a C-terminal caspase activation and recruitment domain (CARD) similar to those found in IAPs. Both RIP and RIP2 can activate NF-kappaB and cause cell death. RIP2 is recruited to TNFRs through interactions with TRAF1, TRAF5, and TRAF6, and RIP2 activation of NF-kappaB requires IKKalpha, IKKbeta, and IKKgamma. In addition, RIP2 can be activated through interactions with Ras-activated Raf1, and RIP2 can activate ERK1 and ERK2. Thus, RIP proteins may regulate TNFR signaling through both ser/thr kinase activity and interaction with the apoptotic machinery.
    分子量
    61 kDa
    途径
    TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
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