UHRF1 抗体 (AA 199-298)
(2 references)-
- 抗原 See all UHRF1 抗体
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
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抗原表位
- AA 199-298
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This UHRF1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Fluorescence Microscopy (FM)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human ICBP90 aa. 199-298
- 克隆位点
- 28-ICBP90
- 亚型
- IgG2a
- Top Product
- Discover our top product UHRF1 Primary Antibody
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anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 1-260) antibody
UHRF1 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 616-755) antibodyUHRF1 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 1A1B1 unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 694-793) antibodyUHRF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 616-755) antibodyUHRF1 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 2A8C7 unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 229-257) antibodyUHRF1 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (N-Term) antibodyUHRF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC, IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) antibodyKO Validated UHRF1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 596-628), (C-Term) antibodyUHRF1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51453 unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (meLys385) antibodyUHRF1 适用: 人 WB, IHC, DB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1) (AA 229-257) antibodyUHRF1 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB21516 unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression." in: Gene, Vol. 266, Issue 1-2, pp. 15-23, (2001) (PubMed).
: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, (2000) (PubMed).
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: "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression." in: Gene, Vol. 266, Issue 1-2, pp. 15-23, (2001) (PubMed).
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- 抗原
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
- 别名
- ICBP90 (UHRF1 产品)
- 别名
- ICBP90 antibody, Np95 antibody, RNF106 antibody, hNP95 antibody, hUHRF1 antibody, AL022808 antibody, NP95 antibody, fb97f09 antibody, wu:fb97f09 antibody, zgc:63539 antibody, UHRF1 antibody, ubiquitin like with PHD and ring finger domains 1 antibody, ubiquitin-like, containing PHD and RING finger domains, 1 antibody, ubiquitin-like with PHD and ring finger domains 1 antibody, UHRF1 antibody, Uhrf1 antibody, uhrf1 antibody
- 背景
- DNA topoisomerases are ubiquitous nuclear enzymes that alter the topology of DNA. Topoisomerase I produces transient single-stranded breaks in DNA, while topoisomerase II produces transient double-stranded breaks in DNA. These DNA breaks are important for DNA replication and chromosome condensation and segregation. Two types of topoisomerase II have been identified, TopoIIalpha and TopoIIbeta. During interphase, TopoIIalpha is found in the nucleoplasm and nucleoli, and in mitosis, TopoIIalpha is found associated with metaphase chromosomes and centromeres. Transcriptional control of TopoIIalpha expression is regulated through multiple gene promoters, which include five inverted CCAAT boxes, one ATF binding sequence, and two GC-rich boxes. ICBP90 was identified in one-hybrid screen of proteins that can bind an inverted CCAAT box. ICBP90 is expressed highest in proliferative tissues such as thymus, liver, and bone marrow. Overexpression of ICBP90 in COS-1-transfected cells leads to enhanced expression of TopoIIalpha. ICBP90 co-localizes with TopoIIalpha in proliferating areas of appendix and in high grade breast carcinomas. Thus, ICBP90 may be an important transcripitonal regulator of TopoIIalpha expression in proliferating cells.
- 分子量
- 97 kDa
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