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Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体

ILF3 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 21-DRBP76 unconjugated
产品编号 ABIN968762
发货至: 中国
  • 抗原 See all Interleukin enhancer-binding factor 3 (ILF3) 抗体
    Interleukin enhancer-binding factor 3 (ILF3)
    抗原表位
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 592-695
    适用
    • 57
    • 40
    • 37
    • 14
    • 11
    • 11
    • 10
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    宿主
    • 53
    • 2
    • 1
    小鼠
    克隆类型
    • 46
    • 11
    单克隆
    标记
    • 43
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    非结合性
    应用范围
    • 37
    • 17
    • 11
    • 10
    • 9
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    产品特性
    1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    4. Please refer to us for technical protocols.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human DRBP76 aa. 592-695
    克隆位点
    21-DRBP76
    亚型
    IgG1
    Top Product
    Discover our top product ILF3 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Saunders, Jurecic, Barber: "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13." in: Genomics, Vol. 71, Issue 2, pp. 256-9, (2001) (PubMed).

    Xu, Grabowski: "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs." in: Molecular genetics and metabolism, Vol. 68, Issue 4, pp. 441-54, (2000) (PubMed).

    Buaas, Lee, Edelhoff, Disteche, Braun: "Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 5, pp. 451-6, (1999) (PubMed).

    Patel, Vestal, Xu, Bandyopadhyay, Guo, Erme, Williams, Sen: "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20432-7, (1999) (PubMed).

  • 抗原
    Interleukin enhancer-binding factor 3 (ILF3)
    别名
    DRBP76 (ILF3 产品)
    别名
    CBTF antibody, DRBF antibody, DRBP76 antibody, MMP4 antibody, MPHOSPH4 antibody, MPP4 antibody, NF-AT-90 antibody, NF110 antibody, NF110b antibody, NF90 antibody, NF90a antibody, NF90b antibody, NFAR antibody, NFAR-1 antibody, NFAR2 antibody, TCP110 antibody, TCP80 antibody, MBII-26 antibody, ilf3 antibody, wu:fb37d07 antibody, wu:fb94b02 antibody, zgc:77030 antibody, 4F.1 antibody, cbtf122 antibody, ilf3-A antibody, ubp3 antibody, ubp4 antibody, xilf3 antibody, interleukin enhancer binding factor 3 antibody, interleukin enhancer binding factor 3b antibody, interleukin enhancer binding factor 3 S homeolog antibody, ILF3 antibody, Ilf3 antibody, ilf3b antibody, ilf3.S antibody
    背景
    The double stranded RNA (dsRNA)-dependent, Ser/Thr protein kinase, PKR, is encoded by an IFN-inducible gene and is critical for the anti-viral responses mediated by IFN. Interaction with activators such as heparin, dsRNA, and the dsRNA-binding proteins (DRBPs), DRBP76, PACT, and RAX, induces PKR autophosphorylation and activation. DRBP76 was identified through its binding to dsRNA and PKR. In addition, DRBP76 has been identified as the alternatively spliced nuclear phosphoproteins of 90 kDa (NFAR-1/NF90) and 110 kDa (NFAR-2), as well as M-phase phosphoprotein (MPP4), translational control protein 80 (TCP80), and interleukin enhancer binding factor 3 (ILF3). DRBP76 contains a bi-partite nuclear localization signal at amino acids 369-373 and 386-394, two DRB domains in the C-terminal half, and a C-terminal RG2 domain that is present in many RNA binding proteins. DRBP76 binds pre-mRNAs and spliced mRNAs, co-localizes with PKR in the nucleus, and is phosphorylated by PKR and possibly cyclin-dependent kinases. Thus, DRBP76 may be one of multiple DRBP variants, which associate with PKR and regulate RNA translation. This antibody is routinely tested by western blot analysis.
    分子量
    90 kDa
    途径
    M Phase
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