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Beclin 1 抗体 (AA 171-291)

BECN1 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IF 宿主: 小鼠 Monoclonal 20-Beclin unconjugated
产品编号 ABIN968743
发货至: 中国
  • 抗原 See all Beclin 1 (BECN1) 抗体
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    抗原表位
    • 16
    • 15
    • 15
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-291
    适用
    • 204
    • 88
    • 72
    • 10
    • 9
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 小鸡
    宿主
    • 173
    • 34
    • 2
    小鼠
    克隆类型
    • 172
    • 37
    单克隆
    标记
    • 93
    • 18
    • 16
    • 15
    • 14
    • 14
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Beclin 1 antibody is un-conjugated
    应用范围
    • 149
    • 99
    • 62
    • 38
    • 32
    • 27
    • 26
    • 22
    • 20
    • 14
    • 13
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    小鼠, 大鼠, 犬, 小鸡
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Beclin aa. 171-291
    克隆位点
    20-Beclin
    亚型
    IgG2a
    Top Product
    Discover our top product BECN1 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Liang, Yu, Brown, Levine: "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function." in: Cancer research, Vol. 61, Issue 8, pp. 3443-9, (2001) (PubMed).

  • 抗原
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    别名
    Beclin (BECN1 产品)
    别名
    beclin-1 antibody, atg6 antibody, vps30 antibody, beclin1 antibody, Beclin-1 antibody, becn1 antibody, zgc:73097 antibody, ATG6 antibody, VPS30 antibody, 4921513J16Rik antibody, 5430417M23Rik antibody, Atg6 antibody, beclin 1 antibody, beclin 1, autophagy related antibody, beclin 1 protein antibody, beclin-1 antibody, beclin family protein antibody, beclin 1, autophagy related L homeolog antibody, BECN1 antibody, becn1 antibody, atg6 antibody, CpipJ_CPIJ011087 antibody, PTRG_07825 antibody, SJAG_01876 antibody, Becn1 antibody, becn1.L antibody
    背景
    Autophagy is the bulk degradation of cellular proteins through the autophagosomic-lysosomal pathway. This process is important for normal cell growth, and may be disrupted in tumor cells. Beclin is a Bcl-2 binding protein that is homologous to the yeast autophagy gene, apg6/vps30. The structure of beclin includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. However, inhibition of CRM1-dependent nuclear export leads to beclin localization primarily in the nucleus. Mutation of the NES domain of beclin also prevents nuclear export, as well as suppresses beclin-mediated nutrient deprivation-induced autophagy. In addition, these beclin mutants can not inhibit in vitro clonigenicity and in vivo tumorigenicity of MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since overexpression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects. Thus, beclin may be an important component of complexes involved in autophagy. This antibody is routinely tested by western blot analysis.
    分子量
    61 kDa
    途径
    Autophagy
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