AP4E1 抗体 (AA 685-793)
AP4E1
适用: 人
WB, IF
宿主: 小鼠
Monoclonal
32-Adaptin epsilon
unconjugated
1 image
(3 references)-
- 抗原 See all AP4E1 抗体
- AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
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抗原表位
- AA 685-793
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This AP4E1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Adaptin epsilon aa. 685-793
- 克隆位点
- 32-Adaptin epsilon
- 亚型
- IgG1
- Top Product
- Discover our top product AP4E1 Primary Antibody
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anti-Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1) (AA 1038-1137) antibody
AP4E1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4." in: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 13145-52, (2001) (PubMed).
: "AP-4, a novel protein complex related to clathrin adaptors." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7278-85, (1999) (PubMed).
: "Characterization of a fourth adaptor-related protein complex." in: Molecular biology of the cell, Vol. 10, Issue 8, pp. 2787-802, (1999) (PubMed).
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: "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4." in: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 13145-52, (2001) (PubMed).
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- 抗原
- AP4E1 (Adaptor-Related Protein Complex 4, epsilon 1 Subunit (AP4E1))
- 别名
- Adaptin epsilon (AP4E1 产品)
- 别名
- CPSQ4 antibody, SPG51 antibody, RGD1562199 antibody, 2310033A20Rik antibody, 9930028M04Rik antibody, AV087807 antibody, adaptor related protein complex 4 epsilon 1 subunit antibody, adaptor-related protein complex 4, epsilon 1 subunit antibody, adaptor-related protein complex AP-4, epsilon 1 antibody, AP4E1 antibody, Ap4e1 antibody
- 背景
- Sorting of integral membrane proteins is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, sigma, epsilon and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain (sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. AP-4 is associated with non-clathrin coated vesicles in the region of the TGN. This localization is disrupted by brefeldin A, indicating that AP-4 membrane attachment is regulated by small GTPases. The µ4 subunit of the AP-4 complex interacts with tyrosine-based signals on LAMP-2 during targeting to the endosomal-lysosomal system. Thus, AP-4 is a less abundant AP complex that may be important for vesicle trafficking from the Golgi to the endosomal-lysosomal system.
- 分子量
- 127 kDa
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