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NLRP2 抗体 (AA 620-732)

NLRP2 适用: 人, 小鼠, 大鼠, 小鸡, 犬 WB, IF 宿主: 小鼠 Monoclonal 34-NBS1 unconjugated
产品编号 ABIN968688
发货至: 中国
  • 抗原 See all NLRP2 抗体
    NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
    抗原表位
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 620-732
    适用
    人, 小鼠, 大鼠, 小鸡, 犬
    宿主
    • 21
    • 5
    • 2
    • 1
    小鼠
    克隆类型
    • 25
    • 4
    单克隆
    标记
    • 29
    This NLRP2 antibody is un-conjugated
    应用范围
    • 26
    • 8
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    小鼠, 大鼠, 犬, 小鸡
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human NBS1 aa. 620-732
    克隆位点
    34-NBS1
    亚型
    IgG1
    Top Product
    Discover our top product NLRP2 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • 抗原
    NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
    别名
    NBS1 (NLRP2 产品)
    别名
    CLR19.9 antibody, NALP2 antibody, NBS1 antibody, PAN1 antibody, PYPAF2 antibody, NLRP2 antibody, E330007A02Rik antibody, Nalp2 antibody, NLR family pyrin domain containing 2 antibody, NACHT, LRR and PYD domains-containing protein 2 antibody, NLR family pyrin domain containing 7 antibody, NLR family, pyrin domain containing 2 antibody, NLRP2 antibody, LOC100301026 antibody, LOC100387349 antibody, NLRP7 antibody, Nlrp2 antibody
    背景
    Nijmegen Breakage Syndrome (NBS) is characterized by extreme radiation sensitivity and chromosomal instability. The NBS1 gene product, p95/nibrin/NBS1, forms a complex with Rad50 and Mre11. Cells deficient in this complex have problems with DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. NBS1 contains a forkhead-associated domain (FHA) and a breast cancer carboxy-terminal domain (BRCT) in the N-terminal region. Both of these domains have been found in DNA-damage responsive cell cycle checkpoint proteins. The complex containing NBS1, Rad50, and Mre11 possesses manganese-dependent single stranded DNA endonuclease and 3' to 5' exonuclease activities. In addition, NBS1 is required for DNA-damage dependent phosphorylation of Mre11. This phosphorylation may be required for proper nuclear localization of the NBS1-Rad50-Mre11 complex to sites of DNA double-strand breaks. NBS1 interacts directly with telomere repeat binding factor, TRF1, via its C-terminal region, and both NBS1 and Mre11 co-localize with TRF1 at promyelocytic leukemia nuclear bodies. Thus, the NBS1-Rad50-Mre11 complex may be important for both DNA damage repair, and telomere length maintenance.
    Synonyms: Nijmegen Breakage Syndrome-1
    分子量
    95 kDa
    途径
    Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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