BID 抗体 (AA 50-62)
(5 references)-
- 抗原 See all BID 抗体
- BID (BH3 Interacting Domain Death Agonist (BID))
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抗原表位
- AA 50-62
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BID antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Bid aa. 50-62
- 克隆位点
- 7-Bid
- 亚型
- IgG1
- Top Product
- Discover our top product BID Primary Antibody
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anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibody
BID 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) antibodyBID 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103) antibodyBID 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0957-RB0958 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-196) antibodyBID 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-130) antibodyBID 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103) antibodyBID 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3F3-1A3 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 39-68) antibodyBID 适用: 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40599-605, (2001) (PubMed).
: "Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44944-52, (2001) (PubMed).
: "p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide." in: The Journal of biological chemistry, Vol. 275, Issue 34, pp. 25939-48, (2000) (PubMed).
: "The destabilization of lipid membranes induced by the C-terminal fragment of caspase 8-cleaved bid is inhibited by the N-terminal fragment." in: The Journal of biological chemistry, Vol. 275, Issue 30, pp. 22713-8, (2000) (PubMed).
: "BID: a novel BH3 domain-only death agonist." in: Genes & development, Vol. 10, Issue 22, pp. 2859-69, (1996) (PubMed).
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: "The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40599-605, (2001) (PubMed).
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- 抗原
- BID (BH3 Interacting Domain Death Agonist (BID))
- 别名
- Bid (BID 产品)
- 别名
- FP497 antibody, 2700049M22Rik antibody, AI875481 antibody, AU022477 antibody, BID antibody, bid antibody, si:ch211-238n5.6 antibody, fp497 antibody, xbid antibody, DKFZp469E066 antibody, BH3 interacting domain death agonist antibody, BH3 interacting domain death agonist S homeolog antibody, BID antibody, Bid antibody, bida antibody, bid.S antibody, bid antibody
- 背景
- Members of the Bcl-2 protein family function to inhibit (Bcl-2, Bcl-XL, Mcl-1, A1) or promote (Bax, Bak, Bcl-Ls, Bad) apoptosis. Bid is a Bcl-2 family death agonist that heterodimerizes with either agonists (Bax) or antagonists (Bcl-2). Bid contains a centrally located BH3 domain that allows interaction with the BH1 domain of Bax and Bcl-2. However, Bid does not contain other domains commonly found in Bcl-2 family members, such as BH1, BH2, or BH4. In addition, Bid does not contain a C-terminal hydrophobic region that is characteristic of membrane-bound Bcl-2 family members. Singlet oxygen-induced apoptosis in human leukemia cells and Fas-induced apoptosis involve caspase-8 cleavage of Bid, which produces a 15 kDa C-terminal fragment and a 6.5 kDa N-terminal fragment. The C-terminal fragment translocates to the mitochondria and promotes the release of cytochrome C through a mechanism that might involve destabilization of the mitochondrial membrane. Thus, the proapoptotic role of Bid may involve mitochondrial membrane destabilization, as well as multiple protein-protein interactions.
- 分子量
- 23 kDa
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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