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KIF3A 抗体 (AA 563-671)

KIF3A 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 28-KIF3A unconjugated
产品编号 ABIN968567
发货至: 中国
  • 抗原 See all KIF3A 抗体
    KIF3A (Kinesin Family Member 3A (KIF3A))
    抗原表位
    • 9
    • 8
    • 3
    • 2
    • 1
    • 1
    AA 563-671
    适用
    • 44
    • 23
    • 14
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 43
    • 1
    小鼠
    克隆类型
    • 43
    • 1
    单克隆
    标记
    • 20
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This KIF3A antibody is un-conjugated
    应用范围
    • 30
    • 18
    • 8
    • 4
    • 4
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    大鼠, 小鼠
    产品特性
    1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    4. Please refer to us for technical protocols.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human KIF3A aa. 563-671
    克隆位点
    28-KIF3A
    亚型
    IgG1
    Top Product
    Discover our top product KIF3A Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Marszalek, Ruiz-Lozano, Roberts, Chien, Goldstein: "Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 5043-8, (1999) (PubMed).

    Muresan, Lyass, Schnapp: "The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 3, pp. 1027-37, (1999) (PubMed).

    Hirokawa: "Kinesin and dynein superfamily proteins and the mechanism of organelle transport." in: Science (New York, N.Y.), Vol. 279, Issue 5350, pp. 519-26, (1998) (PubMed).

  • 抗原
    KIF3A (Kinesin Family Member 3A (KIF3A))
    别名
    KIF3A (KIF3A 产品)
    别名
    FLA10 antibody, KLP-20 antibody, 111-11-71 antibody, 111-11-86 antibody, AW124694 antibody, Kif3 antibody, Kifl antibody, Kns3 antibody, kinesin family member 3A antibody, kinesin family member 3a antibody, KIF3A antibody, Kif3a antibody
    背景
    The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF3A/3B, KRP85/95, and Klp68d/64. These proteins form heterodimeric two-headed motors that interact with kinesin associated protein (KAP). The KIF3A/3B/KAP3 heterotrimeric motor has plus-end directed microtubule sliding activity. This heterotrimeric motor is expressed ubiquitously and is used for anterograde transport of membranous organelles. KIF3A- and KIF3B-deficient mice have defects in the formation of the cilia located in the embryonic node. In addition, KIF3A localizes to the basal body of the connecting cilium axoneme and to vesicles at the pre-synaptic ribbon in photoreceptor cells. Thus, KIF3 motors are involved in microtubule-based formation and movement of cilia and the transport of synaptic vesicles. This antibody is routinely tested by the Western blot analysis.
    分子量
    80/85 kDa
    途径
    Hedgehog Signaling
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