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IRS1 抗体 (AA 1131-1234)

IRS1 适用: 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 6-IRS unconjugated
产品编号 ABIN968514
发货至: 中国
  • 抗原 See all IRS1 抗体
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    抗原表位
    • 31
    • 28
    • 23
    • 21
    • 21
    • 19
    • 18
    • 17
    • 16
    • 16
    • 16
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1131-1234
    适用
    • 292
    • 233
    • 209
    • 23
    • 19
    • 18
    • 17
    • 16
    • 16
    • 15
    • 2
    • 1
    • 1
    小鼠, 大鼠
    宿主
    • 292
    • 12
    小鼠
    克隆类型
    • 285
    • 19
    单克隆
    标记
    • 138
    • 14
    • 12
    • 12
    • 12
    • 12
    • 12
    • 12
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 9
    This IRS1 antibody is un-conjugated
    应用范围
    • 172
    • 126
    • 104
    • 93
    • 92
    • 67
    • 58
    • 51
    • 24
    • 20
    • 13
    • 7
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Rat IRS-1 aa. 1131-1234
    克隆位点
    6-IRS
    亚型
    IgG1
    Top Product
    Discover our top product IRS1 Primary Antibody
  • 说明

    Related Products: ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Obici, Feng, Karkanias, Baskin, Rossetti: "Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats." in: Nature neuroscience, Vol. 5, Issue 6, pp. 566-72, (2002) (PubMed).

    Paz, Liu, Shorer, Hemi, LeRoith, Quan, Kanety, Seger, Zick: "Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function." in: The Journal of biological chemistry, Vol. 274, Issue 40, pp. 28816-22, (1999) (PubMed).

    Kuhné, Zhao, Rowles, Lavan, Shen, Fischer, Lienhard: "Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C." in: The Journal of biological chemistry, Vol. 269, Issue 22, pp. 15833-7, (1994) (PubMed).

    Backer, Myers, Shoelson, Chin, Sun, Miralpeix, Hu, Margolis, Skolnik, Schlessinger: "Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation." in: The EMBO journal, Vol. 11, Issue 9, pp. 3469-79, (1992) (PubMed).

    Sun, Rothenberg, Kahn, Backer, Araki, Wilden, Cahill, Goldstein, White: "Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein." in: Nature, Vol. 352, Issue 6330, pp. 73-7, (1991) (PubMed).

  • 抗原
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    别名
    IRS-1 (IRS1 产品)
    别名
    HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody
    背景
    The IRS (Insulin receptor substrate) proteins IRS-1, IRS-2, IRS-3, and IRS-4 are major substrates of the insulin receptor tyrosine kinase and the insulin-like growth factor-1 receptor. IRS proteins contain an N-terminal pleckstrin homology (PH) domain, an ATP-binding domain, and multiple tyrosine phosphorylation sites in the C-terminus. Following insulin receptor ligation, IRS-1 binds to the juxtamembrane region of the receptor and is tyrosine phosphorylated. This facilitates its interaction with SH2 domain-containing signaling proteins, such as PI3 kinase, fyn, Grb2, and PTP1D. Phosphorylation dramatically reduces the affinity of IRS-1 for the insulin receptor, indicating that dissociation from the receptor and subsequent subcellular translocation are important to IRS-1 function in the pleiotropic effects induced by insulin. In support of this, IRS-1-null mice are viable, but exhibit growth retardation and abnormal glucose metabolism. In cases of reduced IRS-1 expression, certain IRS-1 functions can be assumed by the related IRS-2 protein, while other activities linked to IRS-1 are inhibited. Thus, IRS-1 is an essential component of insulin induced signal transduction. This antibody is routinely tested by western blot analysis.
    分子量
    180 kDa
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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