Endoglin 抗体 (AA 24-144)
(4 references)-
- 抗原 See all Endoglin (ENG) 抗体
- Endoglin (ENG)
-
抗原表位
- AA 24-144
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This Endoglin antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human S-Endoglin aa. 24-144
- 克隆位点
- 35-CD105
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product ENG Primary Antibody
-
anti-Endoglin (ENG) (AA 58-110) antibody
ENG 适用: 人, 小鼠, 大鼠, 犬 WB, FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 27-137) antibodyENG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 26-136) antibodyENG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 26-136) antibodyENG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) antibodyENG 适用: 人 WB, FACS, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Endoglin (ENG) (AA 27-226) antibodyENG 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) (AA 601-658) antibodyENG 适用: 人, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endoglin (ENG) antibodyENG 适用: 人, 大鼠 WB, FACS, IP, CyTOF 宿主: 小鼠 Monoclonal MEM-226 unconjugated
anti-Endoglin (ENG) antibody (APC)ENG 适用: 人, 大鼠 FACS 宿主: 小鼠 Monoclonal MEM-226 APC
anti-Endoglin (ENG) (AA 370-430) antibodyENG 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
- 说明
-
Related Products: ABIN968536, ABIN967389
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
-
-
: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, (1999) (PubMed).
: "Defective angiogenesis in mice lacking endoglin." in: Science (New York, N.Y.), Vol. 284, Issue 5419, pp. 1534-7, (1999) (PubMed).
: "Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions." in: European journal of immunology, Vol. 23, Issue 9, pp. 2340-5, (1993) (PubMed).
: "Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells." in: The Journal of biological chemistry, Vol. 265, Issue 15, pp. 8361-4, (1990) (PubMed).
-
: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, (1999) (PubMed).
-
- 抗原
- Endoglin (ENG)
- 别名
- CD105 (ENG 产品)
- 别名
- ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
- 背景
-
Endoglin (CD105), a major glycoprotein of human vascular endothelium, is a type I integral membrane protein with a large extracellular region, a hydrophobic transmembrane region, and a short cytoplasmic tail. It also contains an RGD tripeptide that may be important for cellular adhesion. There are two forms of endoglin (S-endoglin and L-endoglin) that differ in the length of their cytoplasmic tails. However, the isoforms may have similar functional activity. When overexpressed in fibroblasts, both form disulfide-linked homodimers via their extracellular domains. Endoglin binds TGF-beta1 and TGF-beta3 by associating with TGF-beta type II receptor and binds BMP-7 by associating with activin type II receptor. Thus, endoglin is an accessory protein of multiple TGF-beta superfamily kinase receptor complexes. Loss of function mutations in the human endoglin gene cause hereditary hemorrhagic telangiectasia, which is characterized by vascular malformations. Deletion of endoglin in mice leads to death due to defective vascular development. Thus, endoglin is an endothelial specific cell surface protein that may regulate angiogenesis through interactions with TGF-beta superfamily kinase receptors. This antibody is routinely tested by western blot analysis.
Synonyms: Endoglin - 分子量
- 95 kDa
-
