IKBKG 抗体 (AA 278-396)
(5 references)-
- 抗原 See all IKBKG 抗体
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
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抗原表位
- AA 278-396
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适用
- 人, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IKBKG antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠, 人, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse IKKgamma/NEMO aa. 278-396
- 克隆位点
- 54-IKKgamma-NEMO
- 亚型
- IgG1
- Top Product
- Discover our top product IKBKG Primary Antibody
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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibody
IKBKG 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibodyIKBKG 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 4G9 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 60-120) antibodyIKBKG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-110) antibodyIKBKG 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D4 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (N-Term) antibodyIKBKG 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer31) antibodyIKBKG 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer85) antibodyIKBKG 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibodyIKBKG 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (Ser85) antibodyIKBKG 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) antibodyIKBKG 适用: 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968547, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." in: Immunity, Vol. 18, Issue 1, pp. 13-26, (2003) (PubMed).
: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, (1999) (PubMed).
: "Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17402-5, (1999) (PubMed).
: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, (1998) (PubMed).
: "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation." in: Cell, Vol. 93, Issue 7, pp. 1231-40, (1998) (PubMed).
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: "Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." in: Immunity, Vol. 18, Issue 1, pp. 13-26, (2003) (PubMed).
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- 抗原
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
- 别名
- IKK gamma (IKBKG 产品)
- 别名
- AMCBX1 antibody, FIP-3 antibody, FIP3 antibody, Fip3p antibody, IKK-gamma antibody, IP antibody, IP1 antibody, IP2 antibody, IPD2 antibody, NEMO antibody, ZC2HC9 antibody, 1110037D23Rik antibody, AI848108 antibody, AI851264 antibody, AW124339 antibody, IKK[g] antibody, Nemo antibody, nemo antibody, fj33c07 antibody, wu:fj33c07 antibody, zgc:113492 antibody, MGC97885 antibody, IKBKG antibody, IKBKG_1 antibody, IKBKG_2 antibody, CG16910 antibody, DmIKK-gamma antibody, DmIKKgamma antibody, Dmel\\CG16910 antibody, Dmikkgamma antibody, IKK antibody, IKK[[gamma]] antibody, IKKg antibody, IKKgamma antibody, KEY antibody, Kenny antibody, Key antibody, dIKK antibody, dIKK-gamma antibody, dmIKKgamma antibody, inhibitor of nuclear factor kappa B kinase subunit gamma antibody, inhibitor of kappaB kinase gamma antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antibody, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog antibody, kenny antibody, IKBKG antibody, Ikbkg antibody, ikbkg antibody, ikbkg.L antibody, IKBKG_1 antibody, key antibody
- 背景
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In most cells, NF-kappaB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkappaBalpha, IkappaBbeta, and IkappaBepsilon. Cell stimulation induces the release, activation, and nuclear translocation of NF-kappaB. Release of NF-kappaB results from the phosphorylation and subsequent proteolytic degradation of the IkappaB proteins. Two cytokine-inducible IkappaB kinases (IKKalpha and IKKbeta) phosphorylate and target the IkappaB proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900 kDa multisubunit complex that also contains NF-kappaB/RelA, IkappaBalpha, MEKK1, NIK, IKAP, and IKKgamma/NEMO (NF-kappaB essential modulator). IKKgamma contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKKbeta. IKKgamma, essential for IKKalpha/IKKbeta activation of NF-kappaB, is located functionally and physically upstream of these subunits. In addition, IKKgamma enables the HTLV-1 Tax oncoprotein to interact with IKKbeta, resulting in constitutive activation of NF-kappaB and maintenance of cellular transformation. Thus, IKKgamma is an essential element of the IkappaB complex and an adaptor that mediates stable formation of Tax-IKK complexes.
Synonyms: NEMO - 分子量
- 48 kDa
- 途径
- NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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