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CAMK2A 抗体 (AA 448-460)

CAMK2A 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IF, BI 宿主: 小鼠 Monoclonal 45-CaM Kinase II unconjugated
产品编号 ABIN968457
发货至: 中国
  • 抗原 See all CAMK2A 抗体
    CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
    抗原表位
    • 16
    • 12
    • 11
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 448-460
    适用
    • 76
    • 55
    • 54
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 85
    • 28
    小鼠
    克隆类型
    • 78
    • 35
    单克隆
    标记
    • 60
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This CAMK2A antibody is un-conjugated
    应用范围
    • 86
    • 57
    • 31
    • 24
    • 21
    • 19
    • 15
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), BioImaging (BI)
    交叉反应
    小鼠, 人, 犬
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Rat CaM Kinase IIalpha aa. 448-460
    克隆位点
    45-CaM Kinase II
    亚型
    IgG1
    Top Product
    Discover our top product CAMK2A Primary Antibody
  • 说明

    Related Products: ABIN967389, ABIN968545

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

    Zong, Ren, Young, Pypaert, Mu, Birnbaum, Shulman: "AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 25, pp. 15983-7, (2002) (PubMed).

    Brocke, Chiang, Wagner, Schulman: "Functional implications of the subunit composition of neuronal CaM kinase II." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22713-22, (1999) (PubMed).

    Ishida, Fujisawa: "Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain." in: The Journal of biological chemistry, Vol. 270, Issue 5, pp. 2163-70, (1995) (PubMed).

    Hanson, Schulman: "Neuronal Ca2+/calmodulin-dependent protein kinases." in: Annual review of biochemistry, Vol. 61, pp. 559-601, (1992) (PubMed).

  • 抗原
    CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
    别名
    CaM Kinase II (CAMK2A 产品)
    别名
    camk2 antibody, camk2b antibody, zgc:112538 antibody, zgc:123320 antibody, CAMKA antibody, CaMKII antibody, R74975 antibody, mKIAA0968 antibody, PK2CDD antibody, PKCCD antibody, calcium/calmodulin dependent protein kinase II alpha antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog antibody, calcium/calmodulin-dependent protein kinase II alpha antibody, CAMK2A antibody, camk2a.S antibody, camk2a antibody, Camk2a antibody
    背景
    Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, alpha and beta, at a ratio of 2:1 and homomers of alpha subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the alpha and beta subunits, which results in a substantial increase in its affinity for Ca2+/calmodulin.
    Synonyms: Ca2+/calmodulin-dependent protein kinase II
    分子量
    52 kDa
    途径
    WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction
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