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SRPK2 抗体 (AA 363-485)

SRPK2 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 23-SRPK2 unconjugated
产品编号 ABIN968376
发货至: 中国
  • 抗原 See all SRPK2 抗体
    SRPK2 (SFRS Protein Kinase 2 (SRPK2))
    抗原表位
    • 15
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    AA 363-485
    适用
    • 50
    • 32
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 48
    • 2
    小鼠
    克隆类型
    • 50
    单克隆
    标记
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SRPK2 antibody is un-conjugated
    应用范围
    • 23
    • 21
    • 18
    • 14
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    小鼠, 大鼠, 犬
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human SRPK2 aa. 363-485
    克隆位点
    23-SRPK2
    亚型
    IgG1
    Top Product
    Discover our top product SRPK2 Primary Antibody
  • 说明

    Related Products: ABIN968533, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

  • 抗原
    SRPK2 (SFRS Protein Kinase 2 (SRPK2))
    别名
    SRPK2 (SRPK2 产品)
    别名
    SFRSK2 antibody, AW226533 antibody, AW492537 antibody, AW547358 antibody, Wbp6 antibody, mSRPK2 antibody, sfrsk2 antibody, srpk2 antibody, srpk2-b antibody, srpk2b antibody, SRSF protein kinase 2 antibody, serine/arginine-rich protein specific kinase 2 antibody, SRSF protein kinase 2 L homeolog antibody, SRPK2 antibody, Srpk2 antibody, srpk2 antibody, srpk2.L antibody
    背景
    Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The superfamily of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and their function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate RS domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPK1 is predominate in the pancreas, whereas SRPK2 is highly expressed in brain. SRPK2 contains an N-terminal proline-rich sequence that mediates its in vitro interaction with a WW domain containing protein. SRPKs affect splice-site selection and are thought to affect alternative splicing. This antibody is routinely tested by western blot analysis.
    Synonyms: SR Protein specific Kinase-2
    分子量
    115 kDa
    途径
    Ribonucleoprotein Complex Subunit Organization
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