MST1 抗体 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 331-483)

Details for Product anti-MST1 Antibody No. ABIN968344, 供应商: Log in to see
抗原
  • D3F15S2
  • DNF15S2
  • HGFL
  • MSP
  • NF15S2
  • D3F15S2h
  • D9H3F15S2
  • DNF15S2h
  • Hgfl
  • E2F2
  • HGF1/MSP
  • macrophage stimulating 1 (hepatocyte growth factor-like)
  • Macrophage stimulating 1 (hepatocyte growth factor-like)
  • MST1
  • Mst1
抗原表位
AA 331-483
22
15
15
7
6
6
5
4
3
3
3
2
2
2
1
1
1
1
适用

93
23
19
3
2
2
2
2
1
宿主
小鼠
75
25
克隆类型 (克隆位点)
单克隆 ()
标记
This MST1 antibody is un-conjugated
6
6
5
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunofluorescence (IF), Western Blotting (WB)
80
46
33
18
13
13
5
2
2
2
1
选项
Supplier
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免疫原 Human MST1 aa. 331-483
克隆位点 7-MST1
亚型 IgG1
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 MST1 (MST1 Antibody 摘要)
背景 Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase [PAK]) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42-binding domain. Members of the second class lack GTPase-binding sites, but are similar to the former class throughout the catalytic domain. The latter class includes GC kinase, HPK, KHS, KRS1 & 2, MST1, 2, & 3, and SOK-1. MST1 (Mammalian Sterile Twenty-like-1) is a ubiquitously expressed kinase that contains an N-terminal kinase domain and C-terminal dimerization and inhibitory domains. Apoptotic stimuli, such as anti-Fas, result in cleavage of the C-terminal regulatory domain by caspase-3 or a related caspase, and activation of MST1. Overexpression of MST1 induces caspase activity, apoptotic morphological changes, and the activation of the SAPK and p38 MAPK pathways. Thus, MST1 is thought to function as a component of a positive feedback loop that amplifies the apoptotic response.
Synonyms: Mammalian Sterile Twenty-like 1, Mammalian STE20-like kinase-1
分子量 56 kDa
研究领域 Cancer, Innate Immunity, Signaling
说明

Related Products: ABIN968537, ABIN967389

限制 仅限研究用
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20° C.
厂商提供的图像
Western Blotting (WB) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) Western blot analysis of MST1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TI...
Immunofluorescence (IF) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) Immunofluorescence staining of human endothelial cells.
 image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (Image 3)
Western Blotting (WB) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (Image 4)
有引用在: Lian, Toker, Badwey: "Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 6349-57, 2001 (PubMed).

Creasy, Chernoff: "Cloning and characterization of a human protein kinase with homology to Ste20." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21695-700, 1995 (PubMed).

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