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ITGA3 抗体 (AA 110-325)

ITGA3 适用: 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 42-CD49c unconjugated
产品编号 ABIN968338
发货至: 中国
  • 抗原 See all ITGA3 抗体
    ITGA3 (Integrin, alpha 3 (ITGA3))
    抗原表位
    • 16
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 110-325
    适用
    • 56
    • 36
    • 17
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠, 大鼠, 犬
    宿主
    • 46
    • 22
    • 3
    • 1
    小鼠
    克隆类型
    • 50
    • 25
    单克隆
    标记
    • 36
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA3 antibody is un-conjugated
    应用范围
    • 43
    • 35
    • 22
    • 13
    • 12
    • 9
    • 9
    • 7
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    大鼠, 犬
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse VLA-3alpha aa. 110-325
    克隆位点
    42-CD49c
    亚型
    IgG1
    Top Product
    Discover our top product ITGA3 Primary Antibody
  • 说明

    Related Products: ABIN968547, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Takeuchi, Hirano, Tsuji, Osawa, Irimura: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).

    Takada, Murphy, Pil, Chen, Ginsberg, Hemler: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." in: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, (1991) (PubMed).

  • 抗原
    ITGA3 (Integrin, alpha 3 (ITGA3))
    别名
    CD49c (ITGA3 产品)
    别名
    CD49C antibody, GAP-B3 antibody, GAPB3 antibody, ILNEB antibody, MSK18 antibody, VCA-2 antibody, VL3A antibody, VLA3a antibody, ITGA3 antibody, AA407068 antibody, integrin subunit alpha 3 antibody, integrin subunit alpha 3 S homeolog antibody, integrin alpha 3 antibody, ITGA3 antibody, itga3.S antibody, Itga3 antibody
    背景
    Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
    Synonyms: Integrin alpha3, VLA-3alpha
    分子量
    135 kDa
    途径
    CXCR4-mediated Signaling Events, Integrin Complex
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