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Caspase 2 抗体 (AA 225-401)

CASP2 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 35-Caspase-2-ICH unconjugated
产品编号 ABIN968323
发货至: 中国
  • 抗原 See all Caspase 2 (CASP2) 抗体
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    抗原表位
    • 15
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 225-401
    适用
    • 99
    • 38
    • 25
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 91
    • 6
    • 4
    小鼠
    克隆类型
    • 80
    • 21
    单克隆
    标记
    • 59
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Caspase 2 antibody is un-conjugated
    应用范围
    • 73
    • 34
    • 23
    • 14
    • 14
    • 14
    • 10
    • 8
    • 7
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human ICH-1L aa. 225-401
    克隆位点
    35-Caspase-2-ICH
    亚型
    IgG1
    Top Product
    Discover our top product CASP2 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13430-7, (2002) (PubMed).

    Li, Chen, Sinogeeva, Gorospe, Wersto, Chrest, Barnes, Liu: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, (2002) (PubMed).

    Mancini, Machamer, Roy, Nicholson, Thornberry, Casciola-Rosen, Rosen: "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis." in: The Journal of cell biology, Vol. 149, Issue 3, pp. 603-12, (2000) (PubMed).

    Shibata, Hisahara, Hara, Yamawaki, Fukuuchi, Yuan, Okano, Miura: "Caspases determine the vulnerability of oligodendrocytes in the ischemic brain." in: The Journal of clinical investigation, Vol. 106, Issue 5, pp. 643-53, (2000) (PubMed).

    Wang, Miura, Bergeron, Zhu, Yuan: "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death." in: Cell, Vol. 78, Issue 5, pp. 739-50, (1994) (PubMed).

  • 抗原
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    别名
    Caspase-2 (CASP2 产品)
    别名
    xCaspase-2 antibody, Caspase-2 antibody, ICH-1 antibody, Nedd2 antibody, CASP-2 antibody, ICH1 antibody, NEDD-2 antibody, NEDD2 antibody, PPP1R57 antibody, ICH-1L/1S antibody, ICH1L1S antibody, caspase 2 antibody, caspase 2 L homeolog antibody, caspase-2 antibody, CASP2 antibody, casp2.L antibody, CpipJ_CPIJ008254 antibody, Casp2 antibody
    背景
    Caspase-2/ICH-1 is related to the C. elegans cell death gene product CED-3 and its mammalian homologue interleukin-1beta-converting enzyme (ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice and ced-3 homology. Caspase-2/ICH-1 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis, while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an important dual role in programmed cell death.
    Synonyms: ICH-1L
    分子量
    48 kDa
    途径
    Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
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