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FYB 抗体 (AA 673-783)

Name: FYB 抗体 (AA 673-783)
SKU: ABIN968265
Availability: OutOfStock

FYB 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 5-FYB unconjugated

Western blot analysis of FYB on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152) .

1 image

(4 references)

产品编号 ABIN968265

发货至: 中国

Datasheet as PDF

抗原 See all FYB 抗体

FYB (FYN-Binding Protein (FYB))
抗原表位
15

12

8

6

4

1

1

1

1

1

1

1

1
AA 673-783
适用
51

8

7

4

4

3

2

2

2

2
人
宿主
43

7

1
小鼠
Compatible Secondaries
克隆类型
44

7
单克隆
标记
27

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1
This FYB antibody is un-conjugated
应用范围
35

26

13

13

7

7

3

3

3

2

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human FYB aa. 673-783

克隆位点

5-FYB

亚型

IgG1

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anti-FYN-Binding Protein (FYB) antibody
FYB 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (C-Term) antibody
FYB 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (AA 678-829) antibody
FYB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (Internal Region) antibody
Verified FYB 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (AA 646-695) antibody
FYB 适用: 人, 犬, Bat WB 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (AA 39-88) antibody
FYB 适用: 人, 小鼠, 马, Pig, 猴, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (N-Term) antibody
FYB 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (C-Term) antibody
FYB 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (AA 501-600) antibody
FYB 适用: 人 ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-FYN-Binding Protein (FYB) (AA 501-600) antibody (Biotin)
FYB 适用: 人 ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Geng, Pfister, Kraeft, Rudd: "Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11527-32, (2001) (PubMed).

Oda, Ikeda, Ochs, Druker, Ozaki, Handa, Ariga, Sakiyama, Witte, Wahl: "Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking." in: Blood, Vol. 95, Issue 5, pp. 1663-70, (2000) (PubMed).

da Silva, Li, de Vera, Canto, Findell, Rudd: "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 14, pp. 7493-8, (1997) (PubMed).

Musci, Hendricks-Taylor, Motto, Paskind, Kamens, Turck, Koretzky: "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases." in: The Journal of biological chemistry, Vol. 272, Issue 18, pp. 11674-7, (1997) (PubMed).
抗原

FYB (FYN-Binding Protein (FYB))

别名

FYB (FYB 产品)

别名

fyb antibody, ADAP antibody, PRO0823 antibody, SLAP-130 antibody, B630013F22Rik antibody, FYB-120/130 antibody, Slap130 antibody, p120/130 antibody, p120/p130 antibody, RGD1563421 antibody, FYN-binding protein antibody, FYN binding protein 1 antibody, FYN binding protein antibody, fyb antibody, FYB1 antibody, Fyb antibody, Fyb1 antibody

背景

Engagement of the T cell receptor (TcR) results in the activation of multiple intracellular src protein tyrosine kinases (PTKs) including p56 [lck] and p59 [fyn]. PTK activation induces TcRzeta phosphorylation and the subsequent recruitment and activation of ZAP-70 which specifically phosphorylates SLP-76. SLP-76 interacts with multiple components of T cell signaling pathways, including Grb-2, PLC-gamma, Vav, and SLAP-130 (also known as SLP-76 Associated Phosphoprotein of 130 kDa). SLAP-130 contains multiple tyrosine based motifs, proline base type I and II SH3 domain binding motifs, lysine/glutamic acid rich nuclear localization motifs, and an SH3-like domain. It associates with the SH2 domain of SLP-76 and is phosphorylated by TcR induced PTKs. This protein has also been reported to directly interact with fyn and has been referred to as fyn binding protein (FYB). Co-transfection data has shown that a limited concentration of FYB/SLAP-130 enhances TcR-induced IL-2 production, while overexpression downregulates gene expression. Thus, FYB/SLAP-130 is viewed to be a regulatory component of the fyn/SLP-76 signaling cascade in T cells.
Synonyms: Fyn Binding Protein, SLAP-130

分子量

130 kDa

途径

TCR Signaling, Protein targeting to Nucleus