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GTF2I 抗体 (AA 17-123)

GTF2I 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 42-TFII unconjugated
产品编号 ABIN968264
发货至: 中国
  • 抗原 See all GTF2I 抗体
    GTF2I (General Transcription Factor III (GTF2I))
    抗原表位
    • 13
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 17-123
    适用
    • 64
    • 24
    • 18
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 60
    • 4
    小鼠
    克隆类型
    • 61
    • 3
    单克隆
    标记
    • 37
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GTF2I antibody is un-conjugated
    应用范围
    • 51
    • 32
    • 16
    • 14
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human BAP-135 aa. 17-123
    克隆位点
    42-TFII
    亚型
    IgG1
    Top Product
    Discover our top product GTF2I Primary Antibody
  • 说明

    Related Products: ABIN968535, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Yang, Desiderio: "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 2, pp. 604-9, (1997) (PubMed).

  • 抗原
    GTF2I (General Transcription Factor III (GTF2I))
    别名
    TFII-I (GTF2I 产品)
    别名
    BAP135 antibody, BTKAP1 antibody, DIWS antibody, GTFII-I antibody, IB291 antibody, SPIN antibody, TFII-I antibody, WBS antibody, WBSCR6 antibody, Gtf2ird1 antibody, 6030441I21Rik antibody, BAP-135 antibody, GtfII-I antibody, Spin antibody, bap-135 antibody, bap135 antibody, btkap1 antibody, diws antibody, gtfii-i antibody, ib291 antibody, spin antibody, tfii-i antibody, wbs antibody, wbscr6 antibody, gtf2i antibody, gtf2i.L antibody, general transcription factor IIi antibody, general transcription factor II I antibody, general transcription factor IIi S homeolog antibody, GTF2I antibody, Gtf2i antibody, gtf2i antibody, gtf2i.S antibody
    背景
    General transcription factor II-I (GTF2I/TFII-I/SPIN/BAP-135) is a transcription factor that contains six directly repeated 90-residue regions, which possess helix-loop-helix protein-protein interaction motifs. TFII-I can regulate transcription in T-cells through interaction with the initiator elments (Inrs) within the AdML and Vbeta promoters, and associates with HIV-1, TdT, and ribonucleotide reductase R1 Inrs. In addition, TFII-I associates with the E box motif, the CACGTG sequence, and with serum response element sequences. The helix-loop-helix repeats facilitate TFII-I interaction with other transcription factors, such as USF, Myc, Phox 1, MADS box protein serum response factor, and STATs. TFII-I was also identified as Bruton's tyrosine kinase (btk)-associated protein (BAP-135). TFII-I/BAP-135 is tyrosine phosphorylated by btk and after EGF stimulation, and this phosphorylation enhances TFII-I transcriptional activity. The wide expression of TFII-I and the interaction of TFII-I with various Inrs and transcription factors implicates TFII-I in various signaling pathways that regulate gene transcription.
    Synonyms: BAP-135
    分子量
    135/140 kDa
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