MSH6 抗体 (AA 225-333)
(5 references)-
- 抗原 See all MSH6 抗体
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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抗原表位
- AA 225-333
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MSH6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 犬, 小鼠, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human MSH6 aa. 225-333
- 克隆位点
- 44-MSH6
- 亚型
- IgG1
- Top Product
- Discover our top product MSH6 Primary Antibody
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anti-MutS Homolog 6 (E. Coli) (MSH6) antibody
MSH6 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3-00E-01 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (AA 374-540) antibodyMSH6 适用: 人 WB, IHC, ELISA, IF, Coat, FACS, StM 宿主: 小鼠 Monoclonal MSH6-3086 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) antibodyMSH6 适用: 人 WB, ELISA, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (AA 374-540) antibodyMSH6 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7D9H5 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) antibodyMSH6 适用: 人, 小鼠, 猴 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (AA 374-540) antibodyMSH6 适用: 人 WB, IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal MSH6-3091 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (AA 931-1030) antibodyMSH6 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (AA 217-395) antibodyMSH6 适用: 人, 小鼠, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 1D1C2 unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (N-Term) antibodyMSH6 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MutS Homolog 6 (E. Coli) (MSH6) (Internal Region) antibodyMSH6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968533, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic?" in: Human genetics, Vol. 112, Issue 2, pp. 105-9, (2003) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18061-8, (2002) (PubMed).
: "Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents." in: The Journal of biological chemistry, Vol. 275, Issue 46, pp. 36256-62, (2000) (PubMed).
: "GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells." in: Science (New York, N.Y.), Vol. 268, Issue 5219, pp. 1912-4, (1995) (PubMed).
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: "Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic?" in: Human genetics, Vol. 112, Issue 2, pp. 105-9, (2003) (PubMed).
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- 抗原
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
- 别名
- MSH6 (MSH6 产品)
- 别名
- GTBP antibody, GTMBP antibody, HNPCC5 antibody, HSAP antibody, p160 antibody, cb326 antibody, wu:fb36c12 antibody, LOC100227810 antibody, AU044881 antibody, AW550279 antibody, Gtmbp antibody, mutS homolog 6 antibody, mutS homolog 6 (E. coli) antibody, DNA mismatch repair protein antibody, MSH6 antibody, msh6 antibody, Msh6 antibody
- 背景
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DNA mismatch repair in bacteria is carried out by the MutL, MutH, and MutS proteins. Initial binding of MutS to the mismatched DNA is followed by binding of the MutH endonuclease and MutL. Together these proteins form a complex that mediates excision repair. Mutations or deficiencies of any of these bacterial proteins results in a mutator phenotype that is characterized by genetic instability. MSH2, MSH3, and MSH6 are human homologs of MutS, while MLH1, PMS1, and PMS2 are homologs of MutL. As a heterodimer with MSH2, MSH6 binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes single-base mispairs and insertion/deletion loops. Binding of this complex induces conformational changes in the DNA that lead to the binding of an MLH-PMS1 complex and excision repair. Mutations in the human genes are associated with hereditary nonpolyposis colon cancer (HNPCC), a common hereditary disease in humans. HNPCC is characterized by frequent microsatellite mutations that arise from somatic mutation due to a replication error (RER+) phenotype. This phenotype is analogous to the bacterial system and is directly linked to DNA mismatch repair deficiencies. This antibody is routinely tested by western blot analysis.
Synonyms: GTBP - 分子量
- 160 kDa
- 途径
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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