SSB 抗体 (AA 179-289)
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- 抗原 See all SSB 抗体
- SSB (Sjogren Syndrome Antigen B (SSB))
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抗原表位
- AA 179-289
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适用
- 人, 大鼠, 犬, 兔
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SSB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人, 犬, 兔, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human La Protein aa. 179-289
- 克隆位点
- 44-La Protein
- 亚型
- IgG1
- Top Product
- Discover our top product SSB Primary Antibody
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- 说明
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Related Products: ABIN968551, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5823-32, (1997) (PubMed).
: "Human La protein: a stabilizer of histone mRNA." in: Molecular and cellular biology, Vol. 17, Issue 6, pp. 3028-36, (1997) (PubMed).
: "Genomic structure and amino acid sequence domains of the human La autoantigen." in: The Journal of biological chemistry, Vol. 263, Issue 34, pp. 18043-51, (1989) (PubMed).
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A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5823-32, (1997) (PubMed).
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- 抗原
- SSB (Sjogren Syndrome Antigen B (SSB))
- 别名
- La Protein (SSB 产品)
- 别名
- LARP3 antibody, La antibody, lab1 antibody, larp3 antibody, ssb antibody, Mt-SSB antibody, MtSSB antibody, Ssbp1 antibody, SS-B antibody, laa-a antibody, ssb-a antibody, ssb-b antibody, wu:fb17f11 antibody, zgc:55588 antibody, Sjogren syndrome antigen B antibody, Sjogren syndrome antigen B L homeolog antibody, single stranded DNA binding protein 1 antibody, Sjogren syndrome antigen B S homeolog antibody, Sjogren syndrome antigen B (autoantigen La) antibody, SSB antibody, ssb.L antibody, SSBP1 antibody, Ssb antibody, ssb.S antibody, ssb antibody
- 背景
- La was first found to bind autoantibodies from individuals with Sjogren's syndrome and systemic lupus erythematosus (SLE). La is a transcription factor for RNA polymerase III (Pol III). It participates in the termination of Pol III-mediated transcription and the recycling of the transcriptional machinery. La associates with the 3' oligo U portion of transcripts generated by Pol III. In some cases, this association protects the message from 3' processing. The association of La and mRNA is mediated by the presence of an N-terminal ribonucleoprotein (RNP) consensus sequence in La. The La protein also binds several small RNAs, such as 7S RNA, 5S RNA, and tRNA, and is thought to be involved in their biogenesis. It is known that histone mRNA is stabilized throughout S Phase and is degraded only at the end of S phase. La protein participates in the stabilization of histone mRNA which results in increased production of histone protein. These data suggest that a major function of La is to protect vital nascent transcripts from premature degradation.
- 分子量
- 47 kDa
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