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Rab4 抗体 (AA 97-213)

RAB4A 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 7-Rab4 unconjugated
产品编号 ABIN968232
发货至: 中国
  • 抗原 See all Rab4 (RAB4A) 抗体
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    抗原表位
    • 16
    • 16
    • 7
    • 1
    • 1
    • 1
    AA 97-213
    适用
    • 68
    • 42
    • 24
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 58
    • 8
    • 2
    小鼠
    克隆类型
    • 51
    • 17
    单克隆
    标记
    • 29
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Rab4 antibody is un-conjugated
    应用范围
    • 50
    • 20
    • 17
    • 16
    • 15
    • 14
    • 14
    • 13
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    大鼠, 犬, 小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Rab4 aa. 97-213
    克隆位点
    7-Rab4
    亚型
    IgG1
    Top Product
    Discover our top product RAB4A Primary Antibody
  • 说明

    Related Products: ABIN968545, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Steiner, Sarria, Glauser, Magnin, Catsicas, Hirling: "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD." in: The Journal of cell biology, Vol. 157, Issue 7, pp. 1197-209, (2002) (PubMed).

    Sans, Racca, Petralia, Wang, McCallum, Wenthold: "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 19, pp. 7506-16, (2001) (PubMed).

    Cormont, Bortoluzzi, Gautier, Mari, van Obberghen, Le Marchand-Brustel: "Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6879-86, (1997) (PubMed).

    Zahraoui, Touchot, Chardin, Tavitian: "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion." in: The Journal of biological chemistry, Vol. 264, Issue 21, pp. 12394-401, (1989) (PubMed).

  • 抗原
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    别名
    Rab4 (RAB4A 产品)
    别名
    rab4a antibody, MGC52945 antibody, fc93b03 antibody, wu:fc93b03 antibody, RAB4A antibody, HRES-1/RAB4 antibody, RAB4 antibody, AI848268 antibody, Rab4 antibody, RAB4A, member RAS oncogene family antibody, RAB4a, member RAS oncogene family antibody, rab4a antibody, RAB4A antibody, Rab4a antibody
    背景
    The Rab proteins are small GTP-binding molecules that are localized to specific intracellular vesicles and organelles and are important for vesicular trafficking. The Rab proteins cycle between active GTP-bound and inactive GDP-bound states. Rab4 is associated with early endosomes and recycling vesicles. It is involved in the recycling of receptors to the plasma membrane and regulates membrane recycling from early endosomes. Rab4 has been reported to be membrane-bound during interphase. However, it can be found as a cytosolic protein during mitosis. It is thought that Rab4 is phosphorylated by cdc2/cyclin B during mitosis and that Ser196 on Rab4 is the recognition site of cdc2. Mutation of Ser196 results in Rab4 membrane association during mitosis in an unphosphorylated form. Together this data indicates that Rab4 is phosphorylated by cdc2 on Ser196 which releases it into the cytosol during mitosis. In addition, Rab4 may play a role in insulin-induced glucose transport into rat adipocytes. Rab4 has also been reported to be associated with vesicles that contain GLUT4, a glucose transporter isoform. This antibody is routinely tested by western blot analysis.
    分子量
    25 kDa
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