DLG1 抗体 (AA 5-213)
(5 references)-
- 抗原 See all DLG1 抗体
- DLG1 (Discs, Large Homolog 1 (DLG1))
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抗原表位
- AA 5-213
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适用
- 人, 大鼠, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This DLG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- 交叉反应
- 小鼠, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Dlg aa. 5-213
- 克隆位点
- 12-Dlg
- 亚型
- IgG1
- Top Product
- Discover our top product DLG1 Primary Antibody
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anti-Discs, Large Homolog 1 (DLG1) antibody
DLG1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 662-773) antibodyDLG1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (Internal Region) antibodyDLG1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-190) antibodyDLG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 643-673) antibodyDLG1 适用: 人 WB 宿主: 兔 Polyclonal RB53955 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (N-Term) antibodyDLG1 适用: 人, 大鼠, 小鼠, 犬 WB, IHC, IP, ICC, EM 宿主: 小鼠 Monoclonal RPI 197-4 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B12 unconjugated
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- 说明
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Related Products: ABIN968533, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene." in: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1475-83, (2001) (PubMed).
: "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex." in: The Journal of biological chemistry, Vol. 276, Issue 52, pp. 48627-30, (2001) (PubMed).
: "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding." in: Cancer research, Vol. 60, Issue 1, pp. 35-7, (2000) (PubMed).
: "Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain." in: The Journal of cell biology, Vol. 135, Issue 4, pp. 1125-37, (1997) (PubMed).
: "Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 21, pp. 9818-22, (1994) (PubMed).
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: "Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene." in: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1475-83, (2001) (PubMed).
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- 抗原
- DLG1 (Discs, Large Homolog 1 (DLG1))
- 别名
- Dlg (DLG1 产品)
- 别名
- DLG1 antibody, Dlgh1 antibody, SAP97 antibody, B130052P05Rik antibody, E-dlg/SAP97 antibody, SAP-97 antibody, mKIAA4187 antibody, DLGH1 antibody, dJ1061C18.1.1 antibody, hdlg antibody, discs large MAGUK scaffold protein 1 antibody, discs, large homolog 1 (Drosophila) antibody, DLG1 antibody, Dlg1 antibody
- 背景
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The human homologue of the Drosophila discs large tumor suppressor protein (hDlg) is a member of the MAGUKs (membrane associated guanylate kinases) protein family. Members of this family (PSD-95, ZO-1, ZO-2, and human erythroid p55) are involved in cell structure and signaling events. The hDlg protein consists of several domains: three PDZ (PSD-95/Discs large/ZO-1) domains, an SH3 domain, and a guanylate kinase-like domain. However, hDlg contains a proline rich N-terminus region consisting of two SH3 domain binding sites that are not normally found in the MAGUKs family. The PDZ domains mediate the interaction of several proteins, such as Shaker-type K+ channel proteins and the APC tumor suppressor protein. Dlg is a peripheral membrane that associates with the cytoskeleton. The cellular location and binding sites of Dlg suggest a role in structure, signal transduction, and growth regulation. Supporting these probable Dlg functions are reports demonstrating that recessive mutations in Drosophila dlg lead to imaginal disc neoplasia and death. Also, Dlg has been reported to bind p56 [lck] tyrosine kinase and the Kv1.3 channel in human T lymphocytes.
This antibody clone to Dlg has been reported to immunoprecipitate and weakly recognize PSD-95 on rat cerebrum lysates, presumably due to crossreactivity between homologous regions of the two proteins (i.e amino acid regions 104-119 and 193-198). - 分子量
- 140 kDa
- 途径
- Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response
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