Cathepsin D 抗体
(4 references)-
- 抗原 See all Cathepsin D (CTSD) 抗体
- Cathepsin D (CTSD)
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This Cathepsin D antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Cathepsin D
- 克隆位点
- 49-Cathepsin D
- 亚型
- IgG2a
- Top Product
- Discover our top product CTSD Primary Antibody
-
anti-Cathepsin D (CTSD) (C-Term) antibody
CTSD 适用: 人, 小鼠, 大鼠, Hamster, 猴, Pig, 犬, 马, 兔, Cow, 豚鼠, Cat, Avian, 小鸡, 驴, 山羊, 绵羊 WB, IHC (p), IF, IHC (fro), IEM 宿主: 山羊 Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 66-410) antibodyCTSD 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 1-412) antibodyCTSD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 104-250) antibodyCTSD 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CTSD-3082 unconjugated
anti-Cathepsin D (CTSD) (AA 26-412) antibodyCTSD 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 3F12-1B9 unconjugated
anti-Cathepsin D (CTSD) (AA 21-412) antibodyCTSD 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C9 unconjugated
anti-Cathepsin D (CTSD) (AA 120-407) antibodyCTSD 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 104-250) antibodyCTSD 适用: 人 IHC, IF, StM 宿主: 小鼠 Monoclonal CTSD-3276 unconjugated
anti-Cathepsin D (CTSD) (C-Term) antibodyCTSD 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 101-200) antibodyCTSD 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
- 说明
-
Related Products: ABIN967389, ABIN968587
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
-
-
: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
: "Cloning and sequence analysis of cDNA for human cathepsin D." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, (1985) (PubMed).
: "Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D." in: The Journal of biological chemistry, Vol. 256, Issue 21, pp. 11224-31, (1981) (PubMed).
: "A cathepsin D-like acid proteinase from human gastric mucosa. Purification and characterization." in: Journal of biochemistry, Vol. 87, Issue 3, pp. 725-35, (1980) (PubMed).
-
: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
-
- 抗原
- Cathepsin D (CTSD)
- 别名
- Cathepsin D (CTSD 产品)
- 别名
- catD antibody, fb93e11 antibody, fj17b09 antibody, wu:fb93e11 antibody, wu:fj17b09 antibody, LOC398557 antibody, Cathd antibody, CatD antibody, LOC100136761 antibody, CTSD antibody, DKFZp469J0315 antibody, DDBDRAFT_0205785 antibody, DDBDRAFT_0215012 antibody, DDB_0205785 antibody, DDB_0215012 antibody, CLN10 antibody, CPSD antibody, CD antibody, cathepsin D antibody, cathepsin D S homeolog antibody, lysosomal aspartic protease antibody, cathepsin D-like antibody, ctsd antibody, LOC398557 antibody, ctsd.S antibody, CatD antibody, LOC5567565 antibody, LOC100136761 antibody, CTSD antibody, Cathd antibody, ctsD antibody, catd antibody, Ctsd antibody, LOC443060 antibody
- 背景
- Cathepsin D, an enzyme that degrades proteins, was originally cloned during the search of estrogen responsive genes in MCF-7 cells. Cathepsin D is synthesized as the 43kDa preprocathepsin D that is cleaved to form a 46kDa glycosylated procathepsin D. Procathepsin is then processed into a 44kDa active Cathepsin D. The active and mature forms undergo a further cleavage that yields 28kDa and 15kDa (heavy and light chains, respectively) fragments in SDS-PAGE. The heavy and light chains of Cathepsin D are released into the extracellular medium. The maturation process of Cathepsin D occurs through the transit from the endoplasmic reticulum, Golgi apparatus, and to the lysosomes. Estrogens stimulate cell proliferation in a number of tumor cell lines and anti-estrogen therapy is often used in the treatment of breast cancer patients. Therefore, Cathepsin D, which is estrogen inducible, may have a role during the pathogenesis of breast tumors. Additionally, several other roles have been proposed for this enzyme, such as tissue remodeling, tumor invasion, and embryo implantation.
- 分子量
- 43/28 kDa
- 途径
- Peptide Hormone Metabolism
-
