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SNCA 抗体 (AA 15-123)

SNCA 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal 42-alpha unconjugated
产品编号 ABIN968176
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    抗原表位
    • 73
    • 32
    • 27
    • 23
    • 16
    • 15
    • 13
    • 11
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-123
    适用
    • 306
    • 207
    • 207
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 247
    • 101
    • 6
    • 1
    • 1
    • 1
    小鼠
    克隆类型
    • 231
    • 127
    单克隆
    标记
    • 157
    • 25
    • 22
    • 17
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    This SNCA antibody is un-conjugated
    应用范围
    • 249
    • 171
    • 111
    • 82
    • 80
    • 74
    • 68
    • 54
    • 49
    • 49
    • 23
    • 21
    • 13
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    人, 小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Rat Synuclein-1 aa. 15-123
    克隆位点
    42-alpha
    亚型
    IgG1
    Top Product
    Discover our top product SNCA Primary Antibody
  • 说明

    Related Products: ABIN968545, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Martin, Liu, Chen, Price, Pan, Swaby, Golden: "Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death." in: The Journal of comparative neurology, Vol. 500, Issue 1, pp. 20-46, (2006) (PubMed).

    Liu, Fallon, Lashuel, Liu, Lansbury: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, (2002) (PubMed).

    Jo, McLaurin, Yip, St George-Hyslop, Fraser: "alpha-Synuclein membrane interactions and lipid specificity." in: The Journal of biological chemistry, Vol. 275, Issue 44, pp. 34328-34, (2000) (PubMed).

    Ostrerova-Golts, Petrucelli, Hardy, Lee, Farer, Wolozin: "The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6048-54, (2000) (PubMed).

    van der Putten, Wiederhold, Probst, Barbieri, Mistl, Danner, Kauffmann, Hofele, Spooren, Ruegg, Lin, Caroni, Sommer, Tolnay, Bilbe: "Neuropathology in mice expressing human alpha-synuclein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6021-9, (2000) (PubMed).

    Maroteaux, Campanelli, Scheller: "Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 8, pp. 2804-15, (1988) (PubMed).

  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    alpha -Synuclein (SNCA 产品)
    别名
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    背景
    Synuclein cDNA was isolated from Torpedo californica and found to encode a 143 amino acid neuron-specific protein. In addition, a rat brain cDNA library yielded several clones that encode different proteins with homology to Torpedo Synuclein. A 140 amino acid protein in rat is referred to as Synuclein-1. In situ hybridization shows synuclein mRNAs in discrete areas of rat brain, notably the hippocampus. In humans, two synuclein proteins of 140 and 134 amino acids were sequenced that exhibit a high degree of homology with each other (61% identity) and with previously described Synuclein proteins. The 140 amino acid protein (alpha-Synuclein) is the human homologue of rat Synuclein-1 and is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). The 134 amino acid protein (beta-Synuclein) is the human homologue of bovine phosphoneuroprotein. These proteins are expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. This antibody is routinely tested by western blot analysis.
    分子量
    19 kDa
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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