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XIAP 抗体 (AA 268-426)

XIAP 适用: 人, 小鼠, 大鼠, Frog WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 48-hILP-XIAP unconjugated
产品编号 ABIN968164
发货至: 中国
  • 抗原 See all XIAP 抗体
    XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
    抗原表位
    • 16
    • 12
    • 12
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 268-426
    适用
    • 82
    • 45
    • 31
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠, Frog
    宿主
    • 71
    • 12
    • 1
    小鼠
    克隆类型
    • 72
    • 10
    单克隆
    标记
    • 51
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This XIAP antibody is un-conjugated
    应用范围
    • 70
    • 34
    • 25
    • 18
    • 15
    • 13
    • 13
    • 12
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    大鼠, 小鼠, Frog
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human hILP aa. 268-426
    克隆位点
    48-hILP-XIAP
    亚型
    IgG1
    Top Product
    Discover our top product XIAP Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." in: Genes & development, Vol. 16, Issue 1, pp. 33-45, (2002) (PubMed).

    Martins, Iaccarino, Tenev, Gschmeissner, Totty, Lemoine, Savopoulos, Gray, Creasy, Dingwall, Downward: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, (2002) (PubMed).

    Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, (2000) (PubMed).

    Tamm, Kornblau, Segall, Krajewski, Welsh, Kitada, Scudiero, Tudor, Qui, Monks, Andreeff, Reed: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, (2000) (PubMed).

    Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, (1996) (PubMed).

  • 抗原
    XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
    别名
    hILP (XIAP 产品)
    别名
    API3 antibody, BIRC4 antibody, IAP-3 antibody, ILP1 antibody, MIHA antibody, XLP2 antibody, hIAP-3 antibody, hIAP3 antibody, api3 antibody, birc4 antibody, ilp1 antibody, miha antibody, xlp2 antibody, xxiap antibody, 1110015C02Rik antibody, Aipa antibody, Api3 antibody, Birc4 antibody, IAP3 antibody, ILP-1 antibody, mXIAP antibody, riap3 antibody, fb73d01 antibody, wu:fb73d01 antibody, zgc:91873 antibody, BIRC8 antibody, X-linked inhibitor of apoptosis antibody, X-linked inhibitor of apoptosis L homeolog antibody, XIAP antibody, xiap antibody, xiap.L antibody, Xiap antibody
    背景
    Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
    Synonyms: hILP
    分子量
    57 kDa
    途径
    Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
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