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Ron alpha (AA 40-224) 抗体

适用: 人, 犬, Frog, 小鼠, 大鼠 WB, IF, IP, IHC 宿主: 小鼠 Monoclonal 29-RONalpha unconjugated
产品编号 ABIN968150
发货至: 中国
  • 抗原
    Ron alpha
    抗原表位
    • 1
    • 1
    • 1
    AA 40-224
    适用
    人, 犬, Frog, 小鼠, 大鼠
    宿主
    • 2
    小鼠
    克隆类型
    • 2
    单克隆
    标记
    • 2
    非结合性
    应用范围
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC)
    交叉反应
    犬, 大鼠, 小鼠, Frog
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human RONalpha aa. 40-224
    克隆位点
    29-RONalpha
    亚型
    IgG2b
  • 说明

    Related Products: ABIN968619, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Peace, Hughes, Degen, Waltz: "Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis." in: Oncogene, Vol. 20, Issue 43, pp. 6142-51, (2001) (PubMed).

    Gaudino, Follenzi, Naldini, Collesi, Santoro, Gallo, Godowski, Comoglio: "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP." in: The EMBO journal, Vol. 13, Issue 15, pp. 3524-32, (1994) (PubMed).

    Wang, Ronsin, Gesnel, Coupey, Skeel, Leonard, Breathnach: "Identification of the ron gene product as the receptor for the human macrophage stimulating protein." in: Science (New York, N.Y.), Vol. 266, Issue 5182, pp. 117-9, (1994) (PubMed).

    Ronsin, Muscatelli, Mattei, Breathnach: "A novel putative receptor protein tyrosine kinase of the met family." in: Oncogene, Vol. 8, Issue 5, pp. 1195-202, (1993) (PubMed).

  • 抗原
    Ron alpha
    背景
    RON (Recepteur d'Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150 kDa beta-subunit with the kinase activity and a 40 kDa alpha-chain. Both chains are linked by disulfide bonds and the proper arrangement of the alpha and beta heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCgamma, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney, and testis.
    Synonyms: Recepteur d'Origine Nantaise
    分子量
    40 kDa
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