alpha Adaptin 抗体 (AA 38-215)
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北京 101111
Quick Overview for alpha Adaptin 抗体 (AA 38-215) (ABIN968008)
抗原
See all alpha Adaptin (AP2A1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 38-215
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交叉反应
- 大鼠, 人, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse Adaptin alpha [A] aa. 38-215
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亚型
- IgG1
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anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-727) antibody
Verified AP2A1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 612-661) antibodyAP2A1 适用: 人, 小鼠, 大鼠, 马, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 600-650) antibodyAP2A1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-735), (C-Term) antibodyAP2A1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34053 unconjugated
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif." in: Traffic (Copenhagen, Denmark), Vol. 4, Issue 7, pp. 468-78, (2003) (PubMed).
: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." in: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).
: "Numb is an endocytic protein." in: The Journal of cell biology, Vol. 151, Issue 6, pp. 1345-52, (2001) (PubMed).
: "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18392-8, (2001) (PubMed).
: "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)." in: The Journal of cell biology, Vol. 108, Issue 3, pp. 833-42, (1989) (PubMed).
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- alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
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别名
- Adaptin alpha
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背景
- Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (alpha, gamma, delta, or epsilon and beta1, beta2, beta3, or beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain (sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-2 complex, Adaptin alpha is expressed in two very similar isoforms from two different genes. Adaptin alpha [A] (112kDa) is expressed primarily in brain, while Adaptin alpha [C] (105kDa) is expressed in brain, liver and other tissues. This antibody is routinely tested by western blot analysis.
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分子量
- 112 kDa
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
抗原
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