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CAMK4 抗体 (AA 1-241)

CAMK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 26-CaM Kinase IV unconjugated
产品编号 ABIN967876
发货至: 中国
  • 抗原 See all CAMK4 抗体
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    抗原表位
    • 20
    • 17
    • 11
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-241
    适用
    • 64
    • 54
    • 38
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 67
    • 12
    小鼠
    克隆类型
    • 61
    • 18
    单克隆
    标记
    • 48
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CAMK4 antibody is un-conjugated
    应用范围
    • 70
    • 34
    • 19
    • 19
    • 14
    • 14
    • 11
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human CaM Kinase IV aa. 1-241
    克隆位点
    26-CaM Kinase IV
    亚型
    IgG1
    Top Product
    Discover our top product CAMK4 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Wei, Qiu, Liauw, Robinson, Ho, Chatila, Zhuo: "Calcium calmodulin-dependent protein kinase IV is required for fear memory." in: Nature neuroscience, Vol. 5, Issue 6, pp. 573-9, (2002) (PubMed).

    Slee, Adrain, Martin: "Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 10, pp. 7320-6, (2001) (PubMed).

    Passier, Zeng, Frey, Naya, Nicol, McKinsey, Overbeek, Richardson, Grant, Olson: "CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo." in: The Journal of clinical investigation, Vol. 105, Issue 10, pp. 1395-406, (2000) (PubMed).

    Wayman, Walters, Kolibaba, Soderling, Christian: "CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 811-24, (2000) (PubMed).

    Ohmstede, Bland, Merrill, Sahyoun: "Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 13, pp. 5784-8, (1991) (PubMed).

  • 抗原
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    别名
    CaM Kinase IV (CAMK4 产品)
    别名
    CaMK IV antibody, CaMK-GR antibody, IV antibody, caMK antibody, CAMK4 antibody, A430110E23Rik antibody, AI666733 antibody, CaMKIV antibody, CaMKIV/Gr antibody, D18Bwg0362e antibody, Ccdpk antibody, RATCCDPK antibody, camk4-A antibody, wu:fj42a03 antibody, zgc:110275 antibody, calcium/calmodulin dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV L homeolog antibody, CAMK4 antibody, Camk4 antibody, camk4.L antibody, camk4 antibody
    背景
    CaM-kinase IV (Ca2+/calmodulin-dependent protein kinase IV, also described as CaM-kinase Gr) is activated through the binding of Ca2+/CaM and by phosphorylation. This kinase has high sequence homologies with the catalytic and regulatory domains of CaM-kinase II. CaM-kinase IV is a monomer which is highly expressed in cerebellum, thymus, and testis. Its subcellular distrubution includes localization in both the synaptic regions of the molecular layer of the cerebellum, and the nuclei of cerebellar granule cells. CaM-kinase IV has an autoinhibitory domain within residues 305-321 that can suppress kinase activity in the absence of Ca2+/CaM. This type of domain is common in many other CaM-dependent kinases and phosphatases. CaM-kinase IV does not appear to be significantly activated by autophosphorylation, but it can be activated approximately 5-10-fold when phosphorylated by CaM-kinase IV kinase.
    分子量
    60 kDa
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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