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BCAR1 抗体 (AA 644-819)

BCAR1 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IF, IP, IHC (f) 宿主: 小鼠 Monoclonal 21-p130[Cas] unconjugated
产品编号 ABIN967872
发货至: 中国
  • 抗原 See all BCAR1 抗体
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    抗原表位
    • 28
    • 21
    • 15
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 644-819
    适用
    • 109
    • 61
    • 50
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 小鸡
    宿主
    • 117
    • 8
    • 2
    • 1
    小鼠
    克隆类型
    • 122
    • 6
    单克隆
    标记
    • 61
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    This BCAR1 antibody is un-conjugated
    应用范围
    • 54
    • 40
    • 39
    • 39
    • 25
    • 23
    • 12
    • 10
    • 9
    • 8
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    交叉反应
    人, 小鸡, 犬, 小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Rat p130 [Cas] aa. 644-819
    克隆位点
    21-p130[Cas]
    亚型
    IgG1
    Top Product
    Discover our top product BCAR1 Primary Antibody
  • 说明

    Related Products: ABIN968536, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Hermanto, Zong, Li, Wang: "RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix." in: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2345-65, (2002) (PubMed).

    Nagashima, Endo, Ogita, Kawana, Yamagishi, Kitabatake, Matsuda, Mochizuki: "Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells." in: Molecular biology of the cell, Vol. 13, Issue 12, pp. 4231-42, (2002) (PubMed).

    Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, (2001) (PubMed).

    Kook, Shim, Choi, Ahnn, Kim, Eom, Jung, Paik, Song: "Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells." in: Molecular biology of the cell, Vol. 11, Issue 3, pp. 929-39, (2000) (PubMed).

    Sakai, Iwamatsu, Hirano, Ogawa, Tanaka, Mano, Yazaki, Hirai: "A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner." in: The EMBO journal, Vol. 13, Issue 16, pp. 3748-56, (1994) (PubMed).

  • 抗原
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    别名
    p130 Cas (BCAR1 产品)
    别名
    CAS antibody, CAS1 antibody, CASS1 antibody, CRKAS antibody, P130Cas antibody, AI385681 antibody, Cas antibody, Crkas antibody, P130CAS antibody, MGC68466 antibody, cas antibody, p130cas antibody, BCAR1 antibody, fc17f11 antibody, wu:fc17f11 antibody, zgc:175192 antibody, BCAR1, Cas family scaffolding protein antibody, breast cancer anti-estrogen resistance 1 antibody, breast cancer anti-estrogen resistance 1 L homeolog antibody, breast cancer anti-estrogen resistance protein 1 antibody, BCAR1 antibody, Bcar1 antibody, bcar1.L antibody, bcar1 antibody, LOC100435586 antibody
    背景
    P47 [v-crk] is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-crk protein is a fusion product of the viral gag protein and a part of cellular crk that includes SH2 and SH3 domains. v-crk induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130 [Cas]. p130 [Cas] is tightly associated with v-crk via the SH2 domain of v-crk. Tyrosine phosphorylation of p130 [Cas] occurs in conjunction with cellular transformation in cells that express v-src or v-crk. This phosphorylation leads to a change in p130 [Cas] localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130 [Cas] also associates with v-src, it may be a v-src substrate. This antibody is routinely tested by western blot analysis.
    分子量
    130 kDa
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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