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Cyclin B1 抗体 (AA 14-168)

CCNB1 适用: 人, 大鼠 WB, IF, IP, IHC (f) 宿主: 小鼠 Monoclonal 18-Cyclin B unconjugated
产品编号 ABIN967834
发货至: 中国
  • 抗原 See all Cyclin B1 (CCNB1) 抗体
    Cyclin B1 (CCNB1)
    抗原表位
    • 23
    • 23
    • 23
    • 16
    • 9
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-168
    适用
    • 197
    • 92
    • 60
    • 20
    • 16
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 162
    • 42
    • 1
    小鼠
    克隆类型
    • 156
    • 49
    单克隆
    标记
    • 106
    • 10
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Cyclin B1 antibody is un-conjugated
    应用范围
    • 135
    • 72
    • 57
    • 46
    • 40
    • 40
    • 39
    • 30
    • 26
    • 11
    • 11
    • 11
    • 9
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    交叉反应
    大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Cyclin B aa. 14-168
    克隆位点
    18-Cyclin B
    亚型
    IgG1
    Top Product
    Discover our top product CCNB1 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Miyoshi, Rosner, Nozawa, Byrd, Morgan, Landesman-Bollag, Xu, Seldin, Schmidt, Taketo, Robinson, Cardiff, Hennighausen: "Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors." in: Oncogene, Vol. 21, Issue 36, pp. 5548-56, (2002) (PubMed).

    Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Topper, Campbell, Tugendreich, Daum, Burke, Hieter, Gorbsky: "The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis." in: Cell cycle (Georgetown, Tex.), Vol. 1, Issue 4, pp. 282-92, (2002) (PubMed).

    Takasaki, Kogure, Takeuchi, Kaneda, Yano, Hirokawa, Hirose, Shirai, Hashimoto: "Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 7, pp. 4780-7, (2001) (PubMed).

    Mailand, Falck, Lukas, Syljuâsen, Welcker, Bartek, Lukas: "Rapid destruction of human Cdc25A in response to DNA damage." in: Science (New York, N.Y.), Vol. 288, Issue 5470, pp. 1425-9, (2000) (PubMed).

  • 抗原
    Cyclin B1 (CCNB1)
    别名
    Cyclin B (CCNB1 产品)
    别名
    ccnb antibody, cycb antibody, cb267 antibody, cycb1 antibody, wu:fa19g04 antibody, wu:fb16d01 antibody, wu:fb16e07 antibody, wu:fi21c01 antibody, ccnb1 antibody, MGC53596 antibody, CCNB antibody, Ccnb1-rs1 antibody, Ccnb1-rs13 antibody, CycB1 antibody, Cycb-4 antibody, Cycb-5 antibody, Cycb1-rs1 antibody, cyclin B1 antibody, cyclin B1 S homeolog antibody, ccnb1 antibody, ccnb1.2 antibody, ccnb1.S antibody, CCNB1 antibody, Ccnb1 antibody, ccnb1.2.S antibody
    背景
    The B-type cyclins serve as subunits of the major mitotic protein kinase in many different organisms. In mammals, Cyclin B is a subunit for the cdc2 (Cdk1) protein kinase and is synthesized during late S and G2 phases. Cyclin B associates with inactive cdc2 and facilitates phosphorylation of cdc2 at Thr-14 and Tyr-15. This phosphorylation maintains the inactive state until the end of G2. The inactive Cyclin B-cdc2 complex continues to accumulate in the cytoplasm until the CDC25 phosphatase dephosphorylates Thr-14 and Tyr-15, rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when Cyclin B becomes degraded. This degradation process appears to be ubiquitin-dependent and is necessary for the cell to exit mitosis. Also, the conserved domain in B-type cyclins, known as the P box, is required for CDC25 activation. This antibody is routinely tested by western blot analysis.
    分子量
    62 kDa
    途径
    Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase
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