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FAS 抗体 (AA 1-163)

Name: FAS 抗体 (AA 1-163)
SKU: ABIN967816
Availability: OutOfStock

FAS 适用: 人, 大鼠, 小鼠, 犬, 小鸡 WB, IP, IF, IHC (f) 宿主: 小鼠 Monoclonal 13-Fas unconjugated

Western blot analysis of CD95 on a Daudi cell lysate (Human B lymphoblast, ATCC CCL-213).

Immunohistochemical staining of a formalin-fixed rabbit liver section.

IHC

2 images

(4 references)

产品编号 ABIN967816

发货至: 中国

Datasheet as PDF

抗原 See all FAS 抗体

FAS (TNF Receptor Superfamily, Member 6 (FAS))
抗原表位
25

16

16

8

8

6

5

5

4

4

4

4

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-163
适用
214

67

62

19

6

4

2

2

1

1
人, 大鼠, 小鼠, 犬, 小鸡
宿主
159

89

4

2

1

1

1

1
小鼠
Compatible Secondaries
克隆类型
156

100

1
单克隆
标记
124

27

25

12

10

7

4

4

3

3

3

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This FAS antibody is un-conjugated
应用范围
165

117

74

65

36

35

31

26

26

20

19

9

8

6

5

4

4

2

2

2

2

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

交叉反应

小鸡, 犬, 小鼠, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human Fas aa. 1-163

克隆位点

13-Fas

亚型

IgG2a kappa

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说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Rosen, Coll, Li, Filmus: "Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, (2001) (PubMed).

Zhuang, Demirs, Kochevar: "Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation." in: Oncogene, Vol. 20, Issue 46, pp. 6764-76, (2001) (PubMed).

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, (2000) (PubMed).

Arnold, Seifert, Asadullah, Volk: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, (1999) (PubMed).
抗原

FAS (TNF Receptor Superfamily, Member 6 (FAS))

别名

CD95 (FAS 产品)

别名

ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody

背景

CD95 is a member of a family of cell surface receptors that includes tumor necrosis factor receptor (TNF-R), nerve growth factor receptor (NGF-R), CD40, CD27, CD30, and 4-1BB. Both murine and human Fas genes have been cloned and reportedly share 60% similarity in their amino acid sequences. CD95 (Fas) is a cell surface apoptosis-signaling molecule that is widely expressed in sites such as thymus, liver, heart, and ovary. Abnormalities in the Fas gene correlate with autoimmune features in mice and with unusually high levels of lymphocyte apoptosis in HIV-infected humans. Genetic studies have localized the Fas gene near the lpr (lymphoproliferation disease) locus on mouse chromosome 19 and further characterization reportedly has revealed that lpr is a mutation affecting the function of the Fas gene. This antibody is routinely tested by western blot analysis.
Synonyms: Fas, APO-1

分子量

45 kDa

途径

p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity