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CTNNA1 抗体 (AA 729-906)

CTNNA1 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IF, IP 宿主: 小鼠 Monoclonal 5-a unconjugated
产品编号 ABIN967813
发货至: 中国
  • 抗原 See all CTNNA1 抗体
    CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
    抗原表位
    • 12
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 729-906
    适用
    • 81
    • 48
    • 32
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬, 小鸡
    宿主
    • 65
    • 16
    • 1
    小鼠
    克隆类型
    • 55
    • 27
    单克隆
    标记
    • 47
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTNNA1 antibody is un-conjugated
    应用范围
    • 46
    • 30
    • 20
    • 17
    • 17
    • 13
    • 12
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    人, 小鸡, 犬, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse alpha-Catenin aa. 729-906
    克隆位点
    5-a
    亚型
    IgG1
    Top Product
    Discover our top product CTNNA1 Primary Antibody
  • 说明

    Related Products: ABIN968536, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Baki, Marambaud, Efthimiopoulos, Georgakopoulos, Wen, Cui, Shioi, Koo, Ozawa, Friedrich, Robakis: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).

    Giannini, Vivanco, Kypta: "alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex." in: The Journal of biological chemistry, Vol. 275, Issue 29, pp. 21883-8, (2000) (PubMed).

    Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).

    Hirano, Kimoto, Shimoyama, Hirohashi, Takeichi: "Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization." in: Cell, Vol. 70, Issue 2, pp. 293-301, (1992) (PubMed).

    Herrenknecht, Ozawa, Eckerskorn, Lottspeich, Lenter, Kemler: "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9156-60, (1991) (PubMed).

  • 抗原
    CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
    别名
    alpha-Catenin (CTNNA1 产品)
    别名
    CAP102 antibody, 2010010M04Rik antibody, AA517462 antibody, AI988031 antibody, Catna1 antibody, CG17947 antibody, CT39986 antibody, Dalpha-Cat antibody, Dalpha-cat antibody, DalphaC antibody, Dalphacat antibody, Dmcatp antibody, Dmel\\CG17947 antibody, a-Cat antibody, a-cat antibody, alpha-CAT antibody, alpha-cat antibody, alpha-catenin antibody, alpha-ctn antibody, alphaCAT antibody, alphaCat antibody, alphacat antibody, Alpha-Cat antibody, dgri_GLEANR_3829 antibody, DgriGH19548 antibody, GH19548 antibody, ctnna antibody, cap102 antibody, catna1 antibody, ctnna1 antibody, catenin alpha 1 antibody, catenin (cadherin associated protein), alpha 1 antibody, alpha Catenin antibody, catenin alpha-1 antibody, catenin (cadherin-associated protein), alpha 1 antibody, catenin alpha 1 S homeolog antibody, CTNNA1 antibody, Ctnna1 antibody, alpha-Cat antibody, Dgri\alpha-Cat antibody, Tsp_10127 antibody, ctnna1 antibody, ctnna1.S antibody
    背景
    The catenins (alpha-, beta-, and gamma-) are cytoplasmic proteins that bind to the highly conserved cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). These junctions are critical for cell-cell adhesion, signal transmission between neighboring cells, and for the anchoring of the actin cytoskeleton. alpha-Catenin (CAP102) shows homology to vinculin, while beta-Catenin is similar to plakoglobin or the Drosophila armadillo gene product. alpha-Catenin was identified as an E-Cadherin-associated protein, however, it also appears to interact with other cadherin family members. There are at least two subtypes of alpha-Catenin: alphaE-Catenin and alphaN-Catenin. The predominant form is known as alphaE-Catenin. It is ubiquitously expressed, but at low levels in the nervous system. The expression of alphaN-Catenin is more restricted and this form predominates in the brain. Increased tyrosine phosphorylation of adherens junction proteins can disrupt catenin-cadherin complexes, leading to changes in cell adhesion properties. It has been noted that down-regulation of this group of proteins often precedes metastasis. In fact, data suggests a correlation between deletions within the alpha-Catenin gene and the development of prostate cancer. This antibody is routinely tested by western blot analysis.
    分子量
    102 kDa
    途径
    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location
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