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CNTNAP1 抗体 (AA 1-1513)

CNTNAP1 适用: 人, 小鼠, 大鼠, 犬, 小鸡, Frog WB, IHC, IP, IF 宿主: 小鼠 Monoclonal 30-p190 unconjugated
产品编号 ABIN967780
发货至: 中国
  • 抗原 See all CNTNAP1 抗体
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    抗原表位
    • 16
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-1513
    适用
    • 53
    • 23
    • 15
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 小鸡, Frog
    宿主
    • 51
    • 4
    • 2
    小鼠
    克隆类型
    • 52
    • 5
    单克隆
    标记
    • 20
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CNTNAP1 antibody is un-conjugated
    应用范围
    • 34
    • 18
    • 15
    • 13
    • 13
    • 13
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    交叉反应
    犬, 大鼠, 小鼠, 小鸡, Frog
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human p190 aa. 1-1513
    克隆位点
    30-p190
    亚型
    IgG1
    Top Product
    Discover our top product CNTNAP1 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, (2003) (PubMed).

    Wolf, Draghi, Liang, Dai, Uhrbom, Eklöf, Westermark, Holland, Resh: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." in: Genes & development, Vol. 17, Issue 4, pp. 476-87, (2003) (PubMed).

    Brandt, Gimona, Hillmann, Haller, Mischak: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." in: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).

    Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

    Settleman, Narasimhan, Foster, Weinberg: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." in: Cell, Vol. 69, Issue 3, pp. 539-49, (1992) (PubMed).

  • 抗原
    CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))
    别名
    p190 (CNTNAP1 产品)
    别名
    CNTNAP1 antibody, CASPR antibody, CNTNAP antibody, NRXN4 antibody, P190 antibody, Caspr antibody, AI841080 antibody, NCP1 antibody, Nrxn4 antibody, p190 antibody, shm antibody, contactin associated protein 1 antibody, contactin associated protein-like 1 antibody, CNTNAP1 antibody, cntnap1 antibody, Cntnap1 antibody
    背景
    GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.
    分子量
    190 kDa
    途径
    Cell-Cell Junction Organization
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