EPS8 抗体 (AA 628-821)
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- 抗原 See all EPS8 抗体
- EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
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抗原表位
- AA 628-821
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适用
- 人, 大鼠, 小鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This EPS8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 人, 大鼠, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Eps8 aa. 628-821
- 克隆位点
- 15-Eps8
- 亚型
- IgG1
- Top Product
- Discover our top product EPS8 Primary Antibody
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anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 9-39), (N-Term) antibody
EPS8 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB4003 unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 1-822) antibodyEPS8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (C-Term) antibodyEPS8 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 251-350) antibodyEPS8 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 572-670) antibodyEPS8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (N-Term) antibodyEPS8 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) antibodyEPS8 适用: 大鼠, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) antibodyEPS8 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (C-Term) antibodyVerified EPS8 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 647-696) antibodyEPS8 适用: 人, 大鼠, 小鼠, Pig, Cow, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389, ABIN968550
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, (2001) (PubMed).
: "Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors." in: The Journal of cell biology, Vol. 135, Issue 6 Pt 1, pp. 1633-42, (1997) (PubMed).
: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." in: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).
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: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, (2001) (PubMed).
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- 抗原
- EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
- 别名
- Eps8 (EPS8 产品)
- 别名
- AW261790 antibody, MGC81285 antibody, MGC146320 antibody, zgc:56041 antibody, epidermal growth factor receptor pathway substrate 8 antibody, epidermal growth factor receptor pathway substrate 8 L homeolog antibody, EPS8 antibody, Eps8 antibody, eps8.L antibody, eps8 antibody
- 背景
- The p97 [Eps8] protein, a substrate for EGF-R tyrosine kinase, contains an SH3 domain, but lacks a functional SH2 domain. Antibodies to Eps8 recognize the 97 kDa protein and a less abundant 68 kDa protein. Both forms are tyrosine-phosphorylated following treatment of cells with EGF. It is likely that p68 [Eps8] is synthesized from an alternatively spliced mRNA since two major Eps8-specific mRNAs are detected by Northern analysis. Co-immunoprecipitation studies have demonstrated a physical association between the Eps8 protein and the EGF-R both in vivo and in vitro. For many EGF-R substrates, this interaction is mediated through an SH2 domain of the substrate. Since Eps8 lacks a well defined SH2 domain and a fusion protein containing the SH2-like region of Eps8 could not bind EGF-R, the mechanism of Eps8-EGF-R association remains unclear. Overexpression of Eps8 in fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF, suggesting that Eps8 has a role in the modulation of EGF-R function.
- 分子量
- 97 kDa
- 途径
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization
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