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Fibronectin 抗体

适用: 人, 小鼠, 大鼠, Cow, 小鸡, 犬 WB, IHC, IP, IF 宿主: 小鼠 Monoclonal 10-Fibronectin unconjugated
产品编号 ABIN967729
发货至: 中国
  • 抗原 See all Fibronectin 抗体
    Fibronectin
    适用
    • 106
    • 56
    • 56
    • 23
    • 14
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 小鸡, 犬
    宿主
    • 73
    • 59
    • 5
    • 1
    小鼠
    克隆类型
    • 73
    • 64
    单克隆
    标记
    • 60
    • 19
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Fibronectin antibody is un-conjugated
    应用范围
    • 71
    • 42
    • 38
    • 31
    • 26
    • 20
    • 18
    • 18
    • 18
    • 17
    • 13
    • 13
    • 10
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    交叉反应
    牛, 小鸡, 犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Fibronectin
    克隆位点
    10-Fibronectin
    亚型
    IgG1 kappa
    Top Product
    Discover our top product Fibronectin Primary Antibody
  • 说明

    Related Products: ABIN968533, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Danen, Sonneveld, Brakebusch, Fassler, Sonnenberg: "The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis." in: The Journal of cell biology, Vol. 159, Issue 6, pp. 1071-86, (2002) (PubMed).

    Rhee, Sen, Lu, Wu, Leoni, Rubin, Corr, Carson: "Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas." in: Oncogene, Vol. 21, Issue 43, pp. 6598-605, (2002) (PubMed).

    Zuk, Bonventre, Brown, Matlin: "Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney." in: The American journal of physiology, Vol. 275, Issue 3 Pt 1, pp. C711-31, (1998) (PubMed).

    Chen, Mosher: "Formation of sodium dodecyl sulfate-stable fibronectin multimers. Failure to detect products of thiol-disulfide exchange in cyanogen bromide or limited acid digests of stabilized matrix fibronectin." in: The Journal of biological chemistry, Vol. 271, Issue 15, pp. 9084-9, (1996) (PubMed).

    Sechler, Takada, Schwarzbauer: "Altered rate of fibronectin matrix assembly by deletion of the first type III repeats." in: The Journal of cell biology, Vol. 134, Issue 2, pp. 573-83, (1996) (PubMed).

  • 抗原
    Fibronectin
    Abstract
    Fibronectin 产品
    别名
    FN antibody, cig antibody, fibronectin antibody, finc antibody, lets antibody, msf antibody, CIG antibody, ED-B antibody, FINC antibody, FNZ antibody, GFND antibody, GFND2 antibody, LETS antibody, MSF antibody, E330027I09 antibody, Fn antibody, Fn-1 antibody, FIBNEC antibody, fn-1 antibody, fibronectin 1 antibody, FN1 antibody, fn1 antibody, Fn1 antibody
    背景
    The 240 kDa dimeric fibronectin protein exists in two forms: a soluble protomer in body fluids and an insoluble multimer in the extracellular matrix. The latter is the primary functional form and creates a substrate for cell migration, a role which makes fibronectin vital to embryogenesis and wound response. Fibronectin mediates cytoskeletal organization, cell attachment, and cellular signaling through interactions with cellular receptors. Although various isoforms of fibronectin are derived by alternative splicing, they share a common N-terminus which is a critical region for cell surface binding in an initial step of multimer assembly. Further polymerization steps are regulated by fibronectin/integrin interactions and result in generation of the complex fibrils that constitute the fibronectin matrix.
    Synonyms: FN, LETS
    分子量
    240 kDa
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