(8 references)-
- 抗原 See all TNFRSF4 抗体
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This TNFRSF4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Recombinant Mouse OX-40 3/4 CD4 Chimeric Protein
- 克隆位点
- OX-86
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TNFRSF4 Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 59-205) antibody
TNFRSF4 适用: 人, Chimpanzee FACS, ELISA, IHC, IF, Coat, ISt, StM 宿主: 小鼠 Monoclonal OX40-3108 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-214) antibodyTNFRSF4 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 3G5G7 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody (PE)TNFRSF4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT35 PE
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody (FITC)TNFRSF4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT35 FITC
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibody (APC)TNFRSF4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal Ber-ACT35 APC
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-214) antibodyTNFRSF4 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2D1B8 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 101-200) antibodyTNFRSF4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (fro), IF (cc), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) antibodyTNFRSF4 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM116 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) antibodyTNFRSF4 适用: 人, Non-Human Primate WB, FACS, ELISA, IP, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal Ber-ACT35 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 100-200) antibodyTNFRSF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4° C.
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: "Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6520-9, (2000) (PubMed).
: "CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7058-66, (1999) (PubMed).
: "Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 1, pp. 486-93, (1999) (PubMed).
: "OX-40: life beyond the effector T cell stage." in: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).
: "Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1818-26, (1999) (PubMed).
: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." in: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).
: "Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells." in: Immunity, Vol. 2, Issue 5, pp. 507-21, (1995) (PubMed).
: "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34." in: The EMBO journal, Vol. 13, Issue 17, pp. 3992-4001, (1994) (PubMed).
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: "Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6520-9, (2000) (PubMed).
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- 抗原
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- 别名
- CD134 (TNFRSF4 产品)
- 别名
- TNFRSF4 antibody, ACT35 antibody, CD134 antibody, Ly-70 antibody, Ox40 antibody, TXGP1L antibody, Txgp1 antibody, OX40 antibody, TNF receptor superfamily member 4 antibody, tumor necrosis factor receptor superfamily, member 4 antibody, TNFRSF4 antibody, Tnfrsf4 antibody
- 背景
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The OX-86 mAb reacts with the OX-40 antigen (CD134), also known as OX-40 receptor, which is a 50-kDa type-I membrane glycoprotein that belongs to the NGFR/TNFR superfamily. Mouse CD134 is expressed on activated CD4+ and CD8+ T lymphocytes and has been shown to be the sole receptor for the OX-40 Ligand (OX-40L). In the brains of mice with actively induced experimental allergic encephalomyelitis, the expression of CD134 on CD4+ T lymphocytes correlates with disease progression. The OX-40/OX-40L system supplies a costimulatory signal for T-cell proliferation and B-cell proliferation and differentiation. In addition, OX-40 antigen provides a costimulatory signal that induces T cells to proliferate in a CD28-independent manner. In the intact animal, CD134 does not appear to be essential for many T-cell responses, but it seems to play a major role in the pathogenesis of some autoimmune diseases. The OX-86 mAb stains both CD4+ and CD8+ activated T cells, and this expression pattern has been confirmed using OX-40L-Ig fusion protein. CD134 was also detected, using OX-86 mAb, on B cells after stimulation with anti-IgM plus anti-CD40 mAb HM40-3. OX-86 mAb does not block binding of OX-40L to OX-40, and it stimulates T-cell proliferation mildly.
Synonyms: OX-40 Antigen - 途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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