电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

PDGFRA 抗体

PDGFRA 适用: 小鼠 WB, ELISA, FACS, IHC (fro), Func, IHC (f) 宿主: 大鼠 Monoclonal APA5 unconjugated
产品编号 ABIN967626
发货至: 中国
  • 抗原 See all PDGFRA 抗体
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    适用
    • 247
    • 126
    • 71
    • 19
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 222
    • 40
    • 4
    • 1
    大鼠
    克隆类型
    • 214
    • 53
    单克隆
    标记
    • 114
    • 21
    • 19
    • 15
    • 15
    • 13
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    This PDGFRA antibody is un-conjugated
    应用范围
    • 179
    • 113
    • 71
    • 54
    • 54
    • 41
    • 38
    • 24
    • 23
    • 14
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse PDGF Receptor alpha chain
    克隆位点
    APA5
    亚型
    IgG2a kappa
    Top Product
    Discover our top product PDGFRA Primary Antibody
  • 应用备注
    This antibody has been tested by immunofluorescent staining (Less or equal than 1 µg/million cells) with flow cytometric analysis and immunohistochemical staining of acetone-fixed frozen sections (0.5 - 2.5 µg/ml) to assure specificity and reactivity. Other reported applications include western blot analysis, ELISA, immunohistochemical staining of paraffin-embedded sections, inhibition of ligand binding, and in vivo blocking of PDGF action.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Fruttiger, Calver, Krüger, Mudhar, Michalovich, Takakura, Nishikawa, Richardson: "PDGF mediates a neuron-astrocyte interaction in the developing retina." in: Neuron, Vol. 17, Issue 6, pp. 1117-31, (1997) (PubMed).

    Takakura, Yoshida, Kunisada, Nishikawa, Nishikawa: "Involvement of platelet-derived growth factor receptor-alpha in hair canal formation." in: The Journal of investigative dermatology, Vol. 107, Issue 5, pp. 770-7, (1996) (PubMed).

    Heldin: "Structural and functional studies on platelet-derived growth factor." in: The EMBO journal, Vol. 11, Issue 12, pp. 4251-9, (1992) (PubMed).

  • 抗原
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    别名
    CD140a (PDGFRA 产品)
    别名
    AI115593 antibody, CD140a antibody, Pdgfr-2 antibody, APDGFR antibody, PDGFACE antibody, CD140A antibody, PDGFR-2 antibody, PDGFR2 antibody, RHEPDGFRA antibody, PDGFR antibody, PDGFR-A antibody, platelet derived growth factor receptor alpha antibody, platelet derived growth factor receptor, alpha polypeptide antibody, platelet-derived growth factor receptor, alpha polypeptide L homeolog antibody, platelet-derived growth factor receptor, alpha polypeptide antibody, PDGFRA antibody, Pdgfra antibody, pdgfra.L antibody
    背景
    The APA5 antibody reacts with Platelet-Derived Growth Factor (PDGF) Receptor alpha chain (CD140a, PDGFR-a), a receptor tyrosine kinase which is widely expressed on cells of mesenchymal origin in the embryo and adult and on several other cell types during embryonic development, but not on hematopoietic cells. PDGFR-a binds to PDGF A and B chains, in contrast to PDGFR-b, which binds only to the PDGF B chain. Biologically active PDGF is a disulphide-linked dimer, forming the AA, AB, and BB isoforms. Binding to PDGF Receptor induces the formation of receptor dimers (aa, ab, or bb), autophosphorylation, and internalization. The mAb APA5 has been demonstrated to block binding of PDGF-AA to PDGFR-a-expressing cells in vitro and to block some PDGF-mediated developmental events in vivo.
    Synonyms: PDGF Receptor alpha chain
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
You are here:
客服